Effects of Different Doses of Eucalyptus Oil From Eucalyptus Globulus Labill on Respiratory Tract Immunity and Immune Function in Healthy Rats

Simple item page
aut.relation.articlenumber1287en_NZ
aut.relation.journalFrontiers in Pharmacologyen_NZ
aut.relation.volume11en_NZ
aut.researcherLu, Jun
dc.contributor.authorShao, Jen_NZ
dc.contributor.authorYin, Zen_NZ
dc.contributor.authorWang, Yen_NZ
dc.contributor.authorYang, Yen_NZ
dc.contributor.authorTang, Qen_NZ
dc.contributor.authorZhang, Men_NZ
dc.contributor.authorJiao, Jen_NZ
dc.contributor.authorLiu, Cen_NZ
dc.contributor.authorYang, Men_NZ
dc.contributor.authorZhen, Len_NZ
dc.contributor.authorHassouna, Aen_NZ
dc.contributor.authorWhite, WLen_NZ
dc.contributor.authorLu, Jen_NZ
dc.date.accessioned2020-12-13T22:52:02Z
dc.date.available2020-12-13T22:52:02Z
dc.date.copyright2020en_NZ
dc.date.issued2020en_NZ
dc.description.abstractEucalyptol (1,8-cineole), the major constituent of eucalyptus oil (EO), was used in traditional medicine as a remedy for colds and bronchitis. This study aimed at clarifying the effect of eucalyptol on respiratory immune function of CD8 and CD4 cells, and alveolar macrophages (AM). Thirty male Sprague-Dawley rats were divided into experimental and control groups. The drug was given once a day for 3 weeks and the experimental group was divided according to the eucalyptol dose into: 30, 100, and 300 mg·kg-1 groups. Flow cytometry was used to detect the phagocytic function of CD4, CD8 cells, and AM in the bronchopulmonary lavage fluid. The 30 and 100 mg·kg-1 groups had an up-regulation effect on CD8 (p < 0.05), with no significant effect on macrophage phagocytosis. The 300 mg·kg-1 group had an inhibitory effect on CD8 and macrophage phagocytosis (p < 0.05), with no significant difference in CD4 between groups. Further investigation was conducted to evaluate the effect of EO on immune function in rats by detecting blood T, B, and NK cells using flow cytometry, and blood IgA, IgG, IgM, and IFN-γ levels by ELISA. High dosage of eucalyptol significantly reduced the proportion of blood B and NK cells (p < 0.05). IgA was decreased in the 100 and 300 mg·kg-1 groups (p < 0.05). There are no significant differences between the number of T cells and the IgG, IgM, and IFN-γ levels between experimental and control groups. Rational use of EO containing eucalyptol can improve the immune function of the respiratory tract and the body immunity, while high dose could have damaging effects, through modifying the phagocytic function of CD8 cells and reducing the proportion of blood B cells, NK cells, and IgA.en_NZ
dc.identifier.citationFrontiers in Pharmacology, 11, 1287.
dc.identifier.doi10.3389/fphar.2020.01287en_NZ
dc.identifier.issn1663-9812en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/13873
dc.publisherFrontiers Mediaen_NZ
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fphar.2020.01287/full
dc.rights© 2020 Shao, Yin, Wang, Yang, Tang, Zhang, Jiao, Liu, Yang, Zhen, Hassouna, White and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectEucalyptol; Respiratory tract; Immunity; NK cells; Macrophages; CD4/CD8; T/B cells; Immunoglobulins
dc.titleEffects of Different Doses of Eucalyptus Oil From Eucalyptus Globulus Labill on Respiratory Tract Immunity and Immune Function in Healthy Ratsen_NZ
dc.typeJournal Article
pubs.elements-id392059
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HI Interprofessional 2018 PBRF
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Effects of Different Doses of Eucalyptus Oil From Eucalyptus globulus Labill on Respiratory Tract Immunity and Immune Functi.pdf
Size:
582.98 KB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
AUT Grant of Licence for Tuwhera Aug 2018.pdf
Size:
276.29 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
School of Interprofessional Health Studies