Effect of Lactobacillus Rhamnosus Probiotic in Early Pregnancy on Plasma Conjugated Bile Acids in a Randomised Controlled Trial

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aut.relation.articlenumber209en_NZ
aut.relation.issue1en_NZ
aut.relation.journalNutrientsen_NZ
aut.relation.volume13en_NZ
aut.researcherDrabsch, Julie
dc.contributor.authorChen, Yen_NZ
dc.contributor.authorLu, Jen_NZ
dc.contributor.authorWickens, Ken_NZ
dc.contributor.authorStanley, Ten_NZ
dc.contributor.authorMaude, Ren_NZ
dc.contributor.authorStone, Pen_NZ
dc.contributor.authorBarthow, Cen_NZ
dc.contributor.authorCrane, Jen_NZ
dc.contributor.authorMitchell, EAen_NZ
dc.contributor.authorMerien, Fen_NZ
dc.contributor.authorMurphy, Ren_NZ
dc.date.accessioned2021-02-09T00:31:10Z
dc.date.available2021-02-09T00:31:10Z
dc.date.copyright2021en_NZ
dc.date.issued2021en_NZ
dc.description.abstractWe have previously shown that probiotic supplementation with Lactobacillus rhamnosus HN001 (HN001) led to a reduced incidence of gestational diabetes mellitus (GDM). Here we investigate whether HN001 supplementation resulted in alterations in fasting lipids, insulin resistance, or bile acids (BAs) during pregnancy. Fasting plasma samples collected at 24-30 weeks' gestation, from 348 women randomised at 14-16 weeks' gestation to consume daily probiotic HN001 (n = 172) or a placebo (n = 176) were analysed for lipids, insulin, glucose and BAs. Women supplemented with HN001 had lower fasting glucose compared with placebo (p = 0.040), and lower GDM. Significant differences were found in fasting insulin, HOMA-IR, low density lipoprotein-cholesterol (LDL-c), high density lipoprotein (HDL)-c, triglycerides, total cholesterol, and BAs by GDM status. Lower fasting conjugated BAs were seen in women receiving HN001. A significant decrease of glycocholic acid (GCA) was found in older (age ≥ 35) women who received HN001 (p = 0.005), while GDM women showed significant reduced taurodeoxycholic acid (TDCA) (p = 0.018). Fasting conjugated BA was positively correlated with fasting glucose (r = 0.136, p = 0.020) and fasting insulin (r = 0.113, p = 0.036). Probiotic HN001 supplementation decreases conjugated BAs and might play a role in the improvement of glucose metabolism in women with pregnancy.en_NZ
dc.identifier.citationNutrients, 13(1), 209. doi:10.3390/nu13010209
dc.identifier.doi10.3390/nu13010209en_NZ
dc.identifier.issn2072-6643en_NZ
dc.identifier.issn2072-6643en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/13974
dc.languageengen_NZ
dc.publisherMDPI AGen_NZ
dc.relation.urihttps://www.mdpi.com/2072-6643/13/1/209
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectLC-MSen_NZ
dc.subjectBile acidsen_NZ
dc.subjectConjugated bile acidsen_NZ
dc.subjectGestational diabetesen_NZ
dc.subjectInsulin sensitivityen_NZ
dc.subjectProbioticsen_NZ
dc.subjectRandomised controlled trialen_NZ
dc.titleEffect of Lactobacillus Rhamnosus Probiotic in Early Pregnancy on Plasma Conjugated Bile Acids in a Randomised Controlled Trialen_NZ
dc.typeJournal Article
pubs.elements-id397304
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HI Interprofessional 2018 PBRF
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