Can Offset Analgesia Magnitude Provide Additional Information About Endogenous Pain Modulation in People With Knee Osteoarthritis? An Experimental Study
Date
Authors
Johansson, Elin
Puts, Sofie
Rice, David
Beckwée, David
Leemans, Lynn
Bilterys, Thomas
Schiphof, Dieuwke
Bautmans, Ivan
Coppieters, Iris
Nijs, Jo
Supervisor
Item type
Journal Article
Degree name
Journal Title
Journal ISSN
Volume Title
Publisher
Lippincott, Williams & Wilkins
Abstract
Objectives: To investigate the relationship between offset analgesia magnitude and the responsiveness to conditioned pain modulation (CPM), temporal summation of (second) pain (TSP), and clinical pain severity in people with knee osteoarthritis (KOA). Methods: Electrical stimuli were applied to 88 participants with KOA to measure offset analgesia at the volar forearm of the dominant hand, and CPM and TSP at the most symptomatic knee and ipsilateral volar wrist. Clinical pain severity was assessed using the pain subscale of the Knee injury and Osteoarthritis Outcome Score (KOOSPAIN). Linear mixed effects models evaluated pain modulatory effects across all tests, and Spearman's partial correlations assessed associations between offset analgesia, CPM, TSP, and KOOSPAIN while accounting for covariates of interest. Participants unable to validly finish all psychophysical tests were excluded from effect and correlation analyses but were evaluated for predictors of non-valid completion using bivariate Stochastic Search Variable Selection. Results: Significant pain modulation was observed across all psychophysical tests (P < 0.05) and no meaningful predictors of non-valid test completion were found. Offset analgesia magnitude did not significantly correlate with CPM, TSP, or KOOSPAIN (p ≥ 0.05), with a maximum partial correlation coefficient of ρ = 0.21. Discussion: Offset analgesia was not associated with CPM, TSP, or KOOSPAIN in people with KOA. Despite the lack of case-control studies comparing offset analgesia between people with KOA and healthy controls, these findings suggest that offset analgesia may provide information about endogenous pain modulation beyond CPM and TSP, though its clinical translation remains uncertain.Description
Keywords
32 Biomedical and Clinical Sciences, 3209 Neurosciences, 3202 Clinical Sciences, Osteoarthritis, Pain Research, Neurosciences, Chronic Pain, Arthritis, Clinical Research, Health Disparities, Musculoskeletal, 1103 Clinical Sciences, 1109 Neurosciences, Anesthesiology, 3202 Clinical sciences
Source
Clinical Journal of Pain, ISSN: 0749-8047 (Print); 1536-5409 (Online), Lippincott, Williams & Wilkins, 41(1), e1258-. doi: 10.1097/ajp.0000000000001258
Rights statement
Manuscript version: Author’s Accepted Manuscript. This version may differ from the published version (or Version of Record). The Authors' Accepted Manuscript is available open access under the following conditions: Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/ The Version of Record published in the Clinical Journal of Pain © 2024 Wolters Kluwer Health, Inc. is available at DOI: 10.1097/ajp.0000000000001258