Extracts From New Zealand Undaria Pinnatifida Containing Fucoxanthin As Potential Functional Biomaterials Against Cancer in Vitro

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aut.relation.endpage42
aut.relation.issue2en_NZ
aut.relation.startpage29
aut.relation.volume5en_NZ
aut.researcherLu, Jun
dc.contributor.authorWang, SKen_NZ
dc.contributor.authorLi, Yen_NZ
dc.contributor.authorWhite, WLen_NZ
dc.contributor.authorLu, Jen_NZ
dc.date.accessioned2016-10-11T03:28:28Z
dc.date.available2016-10-11T03:28:28Z
dc.date.copyright2014en_NZ
dc.date.issued2014en_NZ
dc.description.abstractThis study tested extracts from New Zealand seaweed Undaria pinnatifida containing fucoxanthin, in parallel with pure fucoxanthin, in nine human cancer cell lines, for anticancer activity. Growth inhibition effects of extracts from Undaria pinnatifida were found in all types of cancer cell lines in dose- and time- dependent manners. Cytotoxicity of fucoxanthin in three human non-cancer cell lines was also tested. Compared with pure fucoxanthin, our extracts containing low level of fucoxanthin were found to be more effective in inhibiting the growth of lung carcinoma, colon adenocarcinoma and neuroblastoma. Our results suggest that fucoxanthin is a functional biomaterial that may be used as a chemopreventive phytochemical or in combination chemotherapy. Furthermore, we show for the first time that some unknown compounds with potential selective anti-cancer effects may exist in extracts of New Zealand Undaria pinnatifida, and New Zealand Undaria pinnatifida could be used as a source for either functional biomaterial extraction or production of functional food.en_NZ
dc.identifier.citationJournal of Functional Biomaterials, vol.5(2), pp.29 - 42en_NZ
dc.identifier.doi10.3390/jfb5020029en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/10083
dc.publisherMDPI
dc.relation.urihttp://dx.doi.org/10.3390/jfb5020029
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectFucoxanthin; Undaria pinnatifida; Anti-cancer; New Zealand seaweed; Extract
dc.titleExtracts From New Zealand Undaria Pinnatifida Containing Fucoxanthin As Potential Functional Biomaterials Against Cancer in Vitroen_NZ
dc.typeJournal Article
pubs.elements-id168309
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Health Faculty Office
pubs.organisational-data/AUT/Health & Environmental Science/Interprofessional Health
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