Gout Remission as a Goal of Urate-Lowering Therapy: A Critical Review

Simple item page
aut.relation.articlenumber779
aut.relation.issue6
aut.relation.journalPharmaceuticals
aut.relation.volume16
dc.contributor.authorTabi-Amponsah, Adwoa Dansoa
dc.contributor.authorStewart, Sarah
dc.contributor.authorHosie, Graham
dc.contributor.authorStamp, Lisa K
dc.contributor.authorTaylor, William J
dc.contributor.authorDalbeth, Nicola
dc.date.accessioned2023-05-30T02:34:43Z
dc.date.available2023-05-30T02:34:43Z
dc.date.issued2023-05-23
dc.description.abstractUrate-lowering therapies for the management of gout lead to a reduction in serum urate levels, monosodium urate crystal deposition, and the clinical features of gout, including painful and disabling gout flares, chronic gouty arthritis, and tophi. Thus, disease remission is a potential goal of urate-lowering therapy. In 2016, preliminary gout remission criteria were developed by a large group of rheumatologists and researchers with expertise in gout. The preliminary gout remission criteria were defined as: serum urate < 0.36 mmol/L (6 mg/dL); an absence of gout flares; an absence of tophi; pain due to gout < 2 on a 0–10 scale; and a patient global assessment < 2 on a 0–10 scale over a 12-month period. In this critical review, we describe the development of the preliminary gout remission criteria, the properties of the preliminary gout remission criteria, and clinical studies of gout remission in people taking urate-lowering therapy. We also describe a future research agenda for gout remission.
dc.identifier.citationPharmaceuticals, ISSN: 1424-8247 (Print), MDPI AG, 16(6). doi: 10.3390/ph16060779
dc.identifier.doi10.3390/ph16060779
dc.identifier.issn1424-8247
dc.identifier.urihttps://hdl.handle.net/10292/16200
dc.publisherMDPI AG
dc.relation.urihttps://www.mdpi.com/1424-8247/16/6/779
dc.rights.accessrightsOpenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject1115 Pharmacology and Pharmaceutical Sciences
dc.subject3214 Pharmacology and pharmaceutical sciences
dc.titleGout Remission as a Goal of Urate-Lowering Therapy: A Critical Review
dc.typeJournal Article
pubs.elements-id507043
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Dansoa Tabi-Amponsah et al._2023_Gout remission.pdf
Size:
601.4 KB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
Collections
School of Clinical Sciences