Preparation, Characterization, and Immuno-enhancing Activity of Polysaccharides From Glycyrrhiza Uralensis

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aut.relation.articlenumber159en_NZ
aut.relation.issue1en_NZ
aut.relation.journalBiomoleculesen_NZ
aut.relation.volume10en_NZ
aut.researcherDrabsch, Julie
dc.contributor.authorAipire, Aen_NZ
dc.contributor.authorYuan, Pen_NZ
dc.contributor.authorAimaier, Aen_NZ
dc.contributor.authorCai, Sen_NZ
dc.contributor.authorMahabati, Men_NZ
dc.contributor.authorLu, Jen_NZ
dc.contributor.authorYing, Ten_NZ
dc.contributor.authorZhang, Ben_NZ
dc.contributor.authorLi, Jen_NZ
dc.date.accessioned2020-06-28T22:29:18Z
dc.date.available2020-06-28T22:29:18Z
dc.date.copyright2020en_NZ
dc.date.issued2020en_NZ
dc.description.abstractGlycyrrhiza uralensis is a Chinese herbal medicine with various bioactivities. Three fractions (GUPS-I, GUPS-II and GUPS-III) of G. uralensis polysaccharides (GUPS) were obtained with molecular weights of 1.06, 29.1, and 14.9 kDa, respectively. The monosaccharide compositions of GUPS-II and GUPS-III were similar, while that of GUPS-I was distinctively different. The results of scanning electron microscopy, FT-IR, and NMR suggested that GUPS-II and GUPS-III were flaky with a smooth surface and contained α- and β-glycosidic linkages, while GUPS-I was granulated and contained only α-glycosidic linkages. Moreover, GUPS-II and GUPS-III exhibited better bioactivities on the maturation and cytokine production of dendritic cells (DCs) in vitro than that of GUPS-I. An in vivo experiment showed that only GUPS-II significantly enhanced the maturation of DCs. These results indicate that GUPS-II has the potential to be used in combination with cancer immunotherapy to enhance the therapeutic effect.en_NZ
dc.identifier.citationBiomolecules, 10(1), 159. doi:10.3390/biom10010159
dc.identifier.doi10.3390/biom10010159en_NZ
dc.identifier.issn2218-273Xen_NZ
dc.identifier.issn2218-273Xen_NZ
dc.identifier.urihttps://hdl.handle.net/10292/13457
dc.languageengen_NZ
dc.publisherMDPI AGen_NZ
dc.relation.urihttps://www.mdpi.com/2218-273X/10/1/159
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectGlycyrrhiza uralensis polysaccharidesen_NZ
dc.subjectImmuno-enhancing activityen_NZ
dc.subjectMolecular weighten_NZ
dc.subjectMonosaccharide compositionen_NZ
dc.subjectStructural characterizationen_NZ
dc.titlePreparation, Characterization, and Immuno-enhancing Activity of Polysaccharides From Glycyrrhiza Uralensisen_NZ
dc.typeJournal Article
pubs.elements-id368904
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Interprofessional Health
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HI Interprofessional 2018 PBRF
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