Fast release of sulfosalicylic acid from polymer implants consisting of regenerated cellulose/γ-ferric oxide/polypyrrole

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aut.relation.articlenumber474268en_NZ
aut.relation.journalJournal of Applied Chemistryen_NZ
aut.relation.volume2014en_NZ
dark.contributor.authorChowdhury, Nen_NZ
dark.contributor.authorRobertson, JDen_NZ
dark.contributor.authorAl-Jumailyen_NZ
dark.contributor.authorRamosen_NZ
dc.date.accessioned2018-04-03T23:26:54Z
dc.date.available2018-04-03T23:26:54Z
dc.date.copyright2014en_NZ
dc.date.issued2014en_NZ
dc.description.abstractThis work presents a comparative study on the rate of drug release from implantable matrices induced by electric and magnetic fields separately for better biomedical applications. The matrices were prepared by coating γ-ferric oxide dispersed regenerated cellulose film by polypyrrole doped with sulfosalicylic acid as an anti-inflammatory drug. The drug release mechanisms were studied under both the electric and the magnetic fields separately in an acetate buffer solution with pH 5.5 and temperature 37°C during a period of 5 hours. The amount of drug released was analysed by UV-Vis spectrophotometry. The mechanism of drug release from the matrices under electric field includes expansion of conductive polymer chain and the electrostatic force between electron and drug. The drug release mechanism from the matrices under magnetic field is based on the fact that the heat produced locally by magnetic particles loosens the polymer (polypyrrole) chain surrounding the particles. As a result, the drugs attached to the polypyrrole chain come out to the release medium. The matrices showed fast release of drug, that is, more than 60% of the loaded drug was released within 1 h, and are ideal for the treatment of illness in an emergency care.
dc.identifier.citationJournal of Applied Chemistry, Volume 2014 (2014), Article ID 474268, 7 pages
dc.identifier.doi10.1155/2014/474268en_NZ
dc.identifier.issn2314-6923en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/11489
dc.relation.urihttps://www.hindawi.com/journals/jac/2014/474268/en_NZ
dc.rights© 2014 Nargis A. Chowdhury et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.accessrightsOpenAccessen_NZ
dc.titleFast release of sulfosalicylic acid from polymer implants consisting of regenerated cellulose/γ-ferric oxide/polypyrroleen_NZ
dc.typeJournal Article
pubs.elements-id179391
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Design & Creative Technologies
pubs.organisational-data/AUT/Design & Creative Technologies/Engineering, Computer & Mathematical Sciences
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Applied Science
pubs.organisational-data/AUT/Health & Environmental Science/School of Science
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Design and Creative Technologies
pubs.organisational-data/AUT/PBRF/PBRF Design and Creative Technologies/PBRF ECMS
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