Cytotoxicity of Extracts From New Zealand Surf Clams Against Organ Cancer Cell Lines

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aut.relation.endpage14
aut.relation.issue2en_NZ
aut.relation.journalBiomedicinesen_NZ
aut.relation.startpage1
aut.relation.volume7en_NZ
aut.researcherLu, Jun
dc.contributor.authorOdeleye, Ten_NZ
dc.contributor.authorWhite, WLen_NZ
dc.contributor.authorLu, Jen_NZ
dc.date.accessioned2020-06-28T23:02:03Z
dc.date.available2020-06-28T23:02:03Z
dc.date.copyright2019en_NZ
dc.date.issued2019en_NZ
dc.description.abstractIn this study, we examined the cytotoxic effects of four fractions from three species of New Zealand (NZ) surf clam on four common organ cancer cells. In most cases, a dose- and time-dependent inhibition on the proliferation of the cancer cells was observed. This was most significant in WiDr (colon) cells, where the percentages of viability reduced to as low as 6%, 5%, and 17% (at 1000 µg 72 h) by extracts from Diamond shell, Storm shell, and Tua tua species, respectively. A549 (lung) cells were the least susceptible to the treatment, with viability percentages at 82%, 15%, and 45%, under the same conditions. Induction of caspase-dependent apoptosis and alterations to the cell cycle further supported the observed morphological analysis. The ethanol, petroleum ether, and ethyl acetate fractions of NZ surf clam, rich in lipids and proteins, were more potent than their water-based counterpart. This is the first demonstration where extracts from NZ surf clams show the ability to inhibit the growth and proliferation of cancer cell lines. We suggest that NZ surf clam extracts have the potential to be further studied and developed as candidates for cancer supplementary management/treatment.en_NZ
dc.identifier.citationBiomedicines 2019, 7(2), 25; https://doi.org/10.3390/biomedicines7020025
dc.identifier.doi10.3390/biomedicines7020025en_NZ
dc.identifier.issn2227-9059en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/13460
dc.languageengen_NZ
dc.publisherMDPI
dc.relation.urihttps://www.mdpi.com/2227-9059/7/2/25
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectNew Zealanden_NZ
dc.subjectBioactiveen_NZ
dc.subjectExtracten_NZ
dc.subjectNutraceuticalen_NZ
dc.subjectOrgan cancer cellsen_NZ
dc.subjectSurf clamen_NZ
dc.titleCytotoxicity of Extracts From New Zealand Surf Clams Against Organ Cancer Cell Linesen_NZ
dc.typeJournal Article
pubs.elements-id358108
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Interprofessional Health
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HA Science 2018 PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HI Interprofessional 2018 PBRF
pubs.organisational-data/AUT/zTest
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