Gout on CT of the feet: a symmetric arthropathy

aut.researcherRome, Keith
dc.contributor.authorDoyle, Aen_NZ
dc.contributor.authorDalbeth, Nen_NZ
dc.contributor.authorMcQueen, Fen_NZ
dc.contributor.authorBoyer, Len_NZ
dc.contributor.authorDong, Jen_NZ
dc.contributor.authorRome, Ken_NZ
dc.contributor.authorFrecklington, Men_NZ
dc.date.accessioned2016-03-09T23:25:16Z
dc.date.available2016-03-09T23:25:16Z
dc.date.copyright2015-12-04en_NZ
dc.date.issued2015-12-04en_NZ
dc.description.abstractIntroduction The aim of this study was to assess the distribution of bone erosions in the feet of patients with gout using CT and thereby to test the hypothesis that gout is an asymmetric arthropathy. Methods CT scans of both feet were obtained from 25 patients with chronic gout. CT scans were scored for bone erosion using a semi-quantitative method based on the rheumatoid arthritis MRI scoring system (RAMRIS). CT bone erosion was assessed at 22 bones in each foot (total 1,100 bones) by two independent radiologists. Symmetry was assessed by two methods: (i) comparing right and left foot scores for each patient; and (ii) calculating the proportion of paired joints with or without erosions. Results Observer agreement was excellent (intra-class correlation coefficient 0.92). In the group overall, the difference in scores between the feet was not significant (Student's t-test P = 0.8). In 17 of 25 patients, the difference in erosion scores between the two feet was less than the inter-observer difference. In 24 of 25 patients, the proportion of paired joints was greater than 0.5, indicating symmetric disease. Conclusions Erosive disease from gout is, in fact, a symmetric process in our patient group. This finding is contrary to the established view of gout as an asymmetric arthritis and lends new insight into the behaviour of this common disease.
dc.identifier.citationJournal of Medical Imaging and Radiation Oncology, 60: 54–58. doi: 10.1111/1754-9485.12419en_NZ
dc.identifier.doi10.1111/1754-9485.12419
dc.identifier.issn1754-9485en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/9611
dc.publisherJohn Wiley & Sons, Inc.
dc.rightsCopyright © 2015 John Wiley & Sons. All rights reserved. Authors retain the right to place his/her pre-publication version of the work on a personal website or institutional repository. This article may not exactly replicate the final version published in (please see citation) as it is not a copy of this record. An electronic version of this article can be found online at: (Please see Publisher’s Version).
dc.rights.accessrightsOpenAccessen_NZ
dc.titleGout on CT of the feet: a symmetric arthropathyen_NZ
dc.typeJournal Article
pubs.elements-id193695
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
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