Brain Network Changes After the First Seizure: An Insight into Medication Response?
Date
Authors
Pedersen, Mangor
Pardoe, Heath R
Mito, Remika
Sethi, Moksh
Vaughan, David N
Carney, Patrick W
Jackson, Graeme D
Supervisor
Item type
Journal Article
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Journal Title
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Volume Title
Publisher
Oxford University Press
Abstract
After a first epileptic seizure, anti-seizure medications (ASM) can change the likelihood of having a further event. This prospective study aimed to quantify brain network changes associated with taking ASM monotherapy. We applied graph theoretical network analysis to longitudinal resting-state functional MRI (fMRI) data from 28 participants who had recently experienced their first seizure. Participants were imaged before and during long-term ASM therapy, with a mean inter-scan interval of 6.9 months. After commencing ASM, we observed an increase in the clustering coefficient and a decrease in network path length. Brain changes after ASM treatment were most prominent in the superior frontoparietal and inferior fronto-temporal regions. Participants with recurrent seizures display the most pronounced network changes after ASM treatment. This study shows changes in brain network function after ASM administration, particularly in participants with recurrent seizures. Larger studies that ideally include control cohorts are required to understand further the connection between ASM-related brain network changes and longer-term seizure status.Description
Keywords
ASM, anti-seizure medication, fMRI, networks, seizures, 5202 Biological Psychology, 52 Psychology, Brain Disorders, Biomedical Imaging, Neurosciences, Neurodegenerative, Epilepsy, 3202 Clinical sciences, 3209 Neurosciences, 5202 Biological psychology
Source
Brain Communications, ISSN: 2632-1297 (Print); 2632-1297 (Online), Oxford University Press, 6(5), fcae328-. doi: 10.1093/braincomms/fcae328
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© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.