Mechanism of Resveratrol Dimers Isolated from Grape Inhibiting ¹O₂ Induced DNA Damage by UHPLC-QTOF-MS² and UHPLC-QQQ-MS² Analyses

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aut.relation.endpage271
aut.relation.issue3en_NZ
aut.relation.journalBiomedicinesen_NZ
aut.relation.startpage271
aut.relation.volume9en_NZ
aut.researcherHutcheson, Catherine
dc.contributor.authorKong, Qen_NZ
dc.contributor.authorZeng, Qen_NZ
dc.contributor.authorYu, Jen_NZ
dc.contributor.authorXiao, Hen_NZ
dc.contributor.authorLu, Jen_NZ
dc.contributor.authorRen, Xen_NZ
dc.date.accessioned2021-05-19T03:03:23Z
dc.date.available2021-05-19T03:03:23Z
dc.date.copyright2021en_NZ
dc.date.issued2021en_NZ
dc.description.abstractResveratrol dimers have been extensively reported on due to their antioxidative activity. Previous studies revealed that resveratrol dimer has been shown to selectively quench singlet oxygen (1O2), and could protect DNA from oxidative damage. The mechanism of resveratrol dimers protecting DNA against oxidative damage is still not clear. Therefore, in this project, the reactants and products of resveratrol dimers protecting guanine from oxidative damage were qualitatively monitored and quantitatively analyzed by UHPLC-QTOF-MS2 and UHPLC-QQQ-MS2. Results showed that when guanine and resveratrol dimers were attacked by 1O2, mostly resveratrol dimers were oxidized, which protected guanine from oxidation. Resveratrol dimers’ oxidation products were identified and quantified at m/z 467.1134 [M-H]− and 467.1118 [M-H]−, respectively. The resorcinol of resveratrol dimers reacted with singlet oxygen to produce p-benzoquinone, protecting guanine from 1O2 damage. Therefore, it is hereby reported for the first time that the resorcinol ring is the characteristic structure in stilbenes inhibiting 1O2 induced-DNA damage, which provides a theoretical basis for preventing and treating DNA damage-mediated diseases.en_NZ
dc.identifier.citationBiomedicines, 9(3), 271. doi:10.3390/biomedicines9030271
dc.identifier.doi10.3390/biomedicines9030271en_NZ
dc.identifier.issn2227-9059en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/14199
dc.languageenen_NZ
dc.publisherMDPI AGen_NZ
dc.relation.urihttps://www.mdpi.com/2227-9059/9/3/271
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectResveratrol dimers; Antioxidative activity; Singlet oxygen quenching; DNA damage
dc.titleMechanism of Resveratrol Dimers Isolated from Grape Inhibiting ¹O₂ Induced DNA Damage by UHPLC-QTOF-MS² and UHPLC-QQQ-MS² Analysesen_NZ
dc.typeJournal Article
pubs.elements-id399184
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Faculty of Design & Creative Technologies
pubs.organisational-data/AUT/Faculty of Design & Creative Technologies/School of Engineering, Computer & Mathematical Sciences
pubs.organisational-data/AUT/Faculty of Design & Creative Technologies/School of Engineering, Computer & Mathematical Sciences/Institute for Biomedical Technologies
pubs.organisational-data/AUT/Faculty of Health & Environmental Science
pubs.organisational-data/AUT/Faculty of Health & Environmental Science/School of Public Health & Interdisciplinary Studies
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HI Interprofessional 2018 PBRF
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