Molecular basis of chemosensitivity of platinum pre-treated ovarian cancer to chemotherapy
Molecular basis of chemosensitivity of platinum pre-treated ovarian cancer to chemotherapy
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Date
2010-08-24
Authors
Glaysher, S
Gabriel, FG
Johnson, P
Polak, M
Knight, LA
Parker, K
Poole, M
Narayanan, A
Cree, IA
NHS Collaborative Research Programme for Predictive Oncology
Supervisor
Item type
Journal Article
Degree name
Journal Title
Journal ISSN
Volume Title
Publisher
Nature Publishing Group
Abstract
Ovarian cancer shows considerable heterogeneity in its sensitivity to chemotherapy both clinically and in vitro. This study tested the hypothesis that the molecular basis of this difference lies within the known resistance mechanisms inherent to these patients' tumours.
Description
Keywords
Antineoplastic combined chemotherapy protocols , Busulfan , Cisplatin , Deoxycytidine , Drug resistance , Neoplasm , Drug screening assays , Antitumor , Female , Humans , Ovarian neoplasms , Topotecan
Source
Br J Cancer, vol.103(5), pp.656 - 662
Publisher's version
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From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License.