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dc.contributor.authorGBD 2016 Lifetime Risk of Stroke Collaboratorsen_NZ
dc.contributor.authorFeigin, VLen_NZ
dc.contributor.authorNguyen, Gen_NZ
dc.contributor.authorCercy, Ken_NZ
dc.contributor.authorJohnson, COen_NZ
dc.contributor.authorAlam, Ten_NZ
dc.contributor.authorParmar, PGen_NZ
dc.contributor.authorAbajobir, AAen_NZ
dc.contributor.authorAbate, KHen_NZ
dc.contributor.authorAbd-Allah, Fen_NZ
dc.contributor.authorAbejie, ANen_NZ
dc.contributor.authorAbyu, GYen_NZ
dc.contributor.authorAdemi, Zen_NZ
dc.contributor.authorAgarwal, Gen_NZ
dc.contributor.authorAhmed, MBen_NZ
dc.contributor.authorAkinyemi, ROen_NZ
dc.contributor.authorAl-Raddadi, Ren_NZ
dc.contributor.authorAminde, LNen_NZ
dc.contributor.authorAmlie-Lefond, Cen_NZ
dc.contributor.authorAnsari, Hen_NZ
dc.contributor.authorAsayesh, Hen_NZ
dc.contributor.authorAsgedom, SWen_NZ
dc.contributor.authorAtey, TMen_NZ
dc.contributor.authorAyele, HTen_NZ
dc.contributor.authorBanach, Men_NZ
dc.contributor.authorBanerjee, Aen_NZ
dc.contributor.authorBarac, Aen_NZ
dc.contributor.authorBarker-Collo, SLen_NZ
dc.contributor.authorBärnighausen, Ten_NZ
dc.contributor.authorBarregard, Len_NZ
dc.contributor.authorBasu, Sen_NZ
dc.contributor.authorBedi, Nen_NZ
dc.contributor.authorBehzadifar, Men_NZ
dc.contributor.authorBéjot, Yen_NZ
dc.contributor.authorBennett, DAen_NZ
dc.contributor.authorBensenor, IMen_NZ
dc.contributor.authorBerhe, DFen_NZ
dc.contributor.authorBoneya, DJen_NZ
dc.contributor.authorBrainin, Men_NZ
dc.contributor.authorCampos-Nonato, IRen_NZ
dc.contributor.authorCaso, Ven_NZ
dc.contributor.authorCastañeda-Orjuela, CAen_NZ
dc.contributor.authorRivas, JCen_NZ
dc.contributor.authorCatalá-López, Fen_NZ
dc.contributor.authorChristensen, Hen_NZ
dc.contributor.authorCriqui, MHen_NZ
dc.contributor.authorDamasceno, Aen_NZ
dc.contributor.authorDandona, Len_NZ
dc.contributor.authorDandona, Ren_NZ
dc.contributor.authorDavletov, Ken_NZ
dc.contributor.authorde Courten, Ben_NZ
dc.contributor.authordeVeber, Gen_NZ
dc.contributor.authorDokova, Ken_NZ
dc.contributor.authorEdessa, Den_NZ
dc.contributor.authorEndres, Men_NZ
dc.contributor.authorFaraon, EJAen_NZ
dc.contributor.authorFarvid, MSen_NZ
dc.contributor.authorFischer, Fen_NZ
dc.contributor.authorForeman, Ken_NZ
dc.contributor.authorForouzanfar, MHen_NZ
dc.contributor.authorGall, SLen_NZ
dc.contributor.authorGebrehiwot, TTen_NZ
dc.contributor.authorGeleijnse, JMen_NZ
dc.contributor.authorGillum, RFen_NZ
dc.contributor.authorGiroud, Men_NZ
dc.contributor.authorGoulart, ACen_NZ
dc.contributor.authorGupta, Ren_NZ
dc.contributor.authorGupta, Ren_NZ
dc.contributor.authorHachinski, Ven_NZ
dc.contributor.authorHamadeh, RRen_NZ
dc.contributor.authorHankey, GJen_NZ
dc.contributor.authorHareri, HAen_NZ
dc.contributor.authorHavmoeller, Ren_NZ
dc.contributor.authorHay, SIen_NZ
dc.contributor.authorHegazy, MIen_NZ
dc.contributor.authorHibstu, DTen_NZ
dc.contributor.authorJames, SLen_NZ
dc.contributor.authorJeemon, Pen_NZ
dc.contributor.authorJohn, Den_NZ
dc.contributor.authorJonas, JBen_NZ
dc.contributor.authorJóźwiak, Jen_NZ
dc.contributor.authorKalani, Ren_NZ
dc.contributor.authorKandel, Aen_NZ
dc.contributor.authorKasaeian, Aen_NZ
dc.contributor.authorKengne, APen_NZ
dc.contributor.authorKhader, YSen_NZ
dc.contributor.authorKhan, ARen_NZ
dc.contributor.authorKhang, Y-Hen_NZ
dc.contributor.authorKhubchandani, Jen_NZ
dc.contributor.authorKim, Den_NZ
dc.contributor.authorKim, YJen_NZ
dc.contributor.authorKivimaki, Men_NZ
dc.contributor.authorKokubo, Yen_NZ
dc.contributor.authorKolte, Den_NZ
dc.contributor.authorKopec, JAen_NZ
dc.contributor.authorKosen, Sen_NZ
dc.contributor.authorKravchenko, Men_NZ
dc.contributor.authorKrishnamurthi, Ren_NZ
dc.contributor.authorKumar, GAen_NZ
dc.contributor.authorLafranconi, Aen_NZ
dc.contributor.authorLavados, PMen_NZ
dc.contributor.authorLegesse, Yen_NZ
dc.contributor.authorLi, Yen_NZ
dc.contributor.authorLiang, Xen_NZ
dc.contributor.authorLo, WDen_NZ
dc.contributor.authorLorkowski, Sen_NZ
dc.contributor.authorLotufo, PAen_NZ
dc.contributor.authorLoy, CTen_NZ
dc.contributor.authorMackay, MTen_NZ
dc.contributor.authorAbd El Razek, HMen_NZ
dc.contributor.authorMahdavi, Men_NZ
dc.contributor.authorMajeed, Aen_NZ
dc.contributor.authorMalekzadeh, Ren_NZ
dc.contributor.authorMalta, DCen_NZ
dc.contributor.authorMamun, AAen_NZ
dc.contributor.authorMantovani, LGen_NZ
dc.contributor.authorMartins, SCOen_NZ
dc.contributor.authorMate, KKen_NZ
dc.contributor.authorMazidi, Men_NZ
dc.contributor.authorMehata, Sen_NZ
dc.contributor.authorMeier, Ten_NZ
dc.contributor.authorMelaku, YAen_NZ
dc.contributor.authorMendoza, Wen_NZ
dc.contributor.authorMensah, GAen_NZ
dc.contributor.authorMeretoja, Aen_NZ
dc.contributor.authorMezgebe, HBen_NZ
dc.contributor.authorMiazgowski, Ten_NZ
dc.contributor.authorMiller, TRen_NZ
dc.contributor.authorIbrahim, NMen_NZ
dc.contributor.authorMohammed, Sen_NZ
dc.contributor.authorMokdad, AHen_NZ
dc.contributor.authorMoosazadeh, Men_NZ
dc.contributor.authorMoran, AEen_NZ
dc.contributor.authorMusa, KIen_NZ
dc.contributor.authorNegoi, RIen_NZ
dc.contributor.authorNguyen, Men_NZ
dc.contributor.authorNguyen, QLen_NZ
dc.contributor.authorNguyen, THen_NZ
dc.contributor.authorTran, TTen_NZ
dc.contributor.authorNguyen, TTen_NZ
dc.contributor.authorAnggraini Ningrum, DNen_NZ
dc.contributor.authorNorrving, Ben_NZ
dc.contributor.authorNoubiap, JJen_NZ
dc.contributor.authorO’Donnell, MJen_NZ
dc.contributor.authorOlagunju, ATen_NZ
dc.contributor.authorOnuma, OKen_NZ
dc.contributor.authorOwolabi, MOen_NZ
dc.contributor.authorParsaeian, Men_NZ
dc.contributor.authorPatton, GCen_NZ
dc.contributor.authorPiradov, Men_NZ
dc.contributor.authorPletcher, MAen_NZ
dc.contributor.authorPourmalek, Fen_NZ
dc.contributor.authorPrakash, Ven_NZ
dc.contributor.authorQorbani, Men_NZ
dc.contributor.authorRahman, Men_NZ
dc.contributor.authorRahman, MAen_NZ
dc.contributor.authorRai, RKen_NZ
dc.contributor.authorRanta, Aen_NZ
dc.contributor.authorRawaf, Den_NZ
dc.contributor.authorRawaf, Sen_NZ
dc.contributor.authorRenzaho, AMNen_NZ
dc.contributor.authorRobinson, SRen_NZ
dc.contributor.authorSahathevan, Ren_NZ
dc.contributor.authorSahebkar, Aen_NZ
dc.contributor.authorSalomon, JAen_NZ
dc.contributor.authorSantalucia, Pen_NZ
dc.contributor.authorSantos, ISen_NZ
dc.contributor.authorSartorius, Ben_NZ
dc.contributor.authorSchutte, AEen_NZ
dc.contributor.authorSepanlou, SGen_NZ
dc.contributor.authorShafieesabet, Aen_NZ
dc.contributor.authorShaikh, MAen_NZ
dc.contributor.authorShamsizadeh, Men_NZ
dc.contributor.authorSheth, KNen_NZ
dc.contributor.authorSisay, Men_NZ
dc.contributor.authorShin, M-Jen_NZ
dc.contributor.authorShiue, Ien_NZ
dc.contributor.authorSilva, DASen_NZ
dc.contributor.authorSobngwi, Een_NZ
dc.contributor.authorSoljak, Men_NZ
dc.contributor.authorSorensen, RJDen_NZ
dc.contributor.authorSposato, LAen_NZ
dc.contributor.authorStranges, Sen_NZ
dc.contributor.authorSuliankatchi, RAen_NZ
dc.contributor.authorTabarés-Seisdedos, Ren_NZ
dc.contributor.authorTanne, Den_NZ
dc.contributor.authorNguyen, CTen_NZ
dc.contributor.authorThakur, JSen_NZ
dc.contributor.authorThrift, AGen_NZ
dc.contributor.authorTirschwell, DLen_NZ
dc.contributor.authorTopor-Madry, Ren_NZ
dc.contributor.authorTran, BXen_NZ
dc.contributor.authorNguyen, LTen_NZ
dc.contributor.authorTruelsen, Ten_NZ
dc.contributor.authorTsilimparis, Nen_NZ
dc.contributor.authorTyrovolas, Sen_NZ
dc.contributor.authorUkwaja, KNen_NZ
dc.contributor.authorUthman, OAen_NZ
dc.contributor.authorVarakin, Yen_NZ
dc.contributor.authorVasankari, Ten_NZ
dc.contributor.authorVenketasubramanian, Nen_NZ
dc.contributor.authorVlassov, VVen_NZ
dc.contributor.authorWang, Wen_NZ
dc.contributor.authorWerdecker, Aen_NZ
dc.contributor.authorWolfe, CDAen_NZ
dc.contributor.authorXu, Gen_NZ
dc.contributor.authorYano, Yen_NZ
dc.contributor.authorYonemoto, Nen_NZ
dc.contributor.authorYu, Cen_NZ
dc.contributor.authorZaidi, Zen_NZ
dc.contributor.authorEl Sayed Zaki, Men_NZ
dc.contributor.authorZhou, Men_NZ
dc.contributor.authorZiaeian, Ben_NZ
dc.contributor.authorZipkin, Ben_NZ
dc.contributor.authorVos, Ten_NZ
dc.contributor.authorNaghavi, Men_NZ
dc.contributor.authorMurray, CJLen_NZ
dc.contributor.authorRoth, GAen_NZ
dc.date.accessioned2019-01-09T01:42:37Z
dc.date.available2019-01-09T01:42:37Z
dc.date.copyright2018en_NZ
dc.identifier.citationNew England Journal of Medicine, 379(25), 2429-2437.en_NZ
dc.identifier.issn0028-4793en_NZ
dc.identifier.issn1533-4406en_NZ
dc.identifier.urihttp://hdl.handle.net/10292/12139
dc.description.abstractBACKGROUND: The lifetime risk of stroke has been calculated in a limited number of selected populations. We sought to estimate the lifetime risk of stroke at the regional, country, and global level using data from a comprehensive study of the prevalence of major diseases. METHODS: We used the Global Burden of Disease (GBD) Study 2016 estimates of stroke incidence and the competing risks of death from any cause other than stroke to calculate the cumulative lifetime risks of first stroke, ischemic stroke, or hemorrhagic stroke among adults 25 years of age or older. Estimates of the lifetime risks in the years 1990 and 2016 were compared. Countries were categorized into quintiles of the sociodemographic index (SDI) used in the GBD Study, and the risks were compared across quintiles. Comparisons were made with the use of point estimates and uncertainty intervals representing the 2.5th and 97.5th percentiles around the estimate. RESULTS: The estimated global lifetime risk of stroke from the age of 25 years onward was 24.9% (95% uncertainty interval, 23.5 to 26.2); the risk among men was 24.7% (95% uncertainty interval, 23.3 to 26.0), and the risk among women was 25.1% (95% uncertainty interval, 23.7 to 26.5). The risk of ischemic stroke was 18.3%, and the risk of hemorrhagic stroke was 8.2%. In high-SDI, high-middle-SDI, and low-SDI countries, the estimated lifetime risk of stroke was 23.5%, 31.1% (highest risk), and 13.2% (lowest risk), respectively; the 95% uncertainty intervals did not overlap between these categories. The highest estimated lifetime risks of stroke according to GBD region were in East Asia (38.8%), Central Europe (31.7%), and Eastern Europe (31.6%), and the lowest risk was in eastern sub-Saharan Africa (11.8%). The mean global lifetime risk of stroke increased from 22.8% in 1990 to 24.9% in 2016, a relative increase of 8.9% (95% uncertainty interval, 6.2 to 11.5); the competing risk of death from any cause other than stroke was considered in this calculation. CONCLUSIONS: In 2016, the global lifetime risk of stroke from the age of 25 years onward was approximately 25% among both men and women. There was geographic variation in the lifetime risk of stroke, with the highest risks in East Asia, Central Europe, and Eastern Europe. (Funded by the Bill and Melinda Gates Foundation.).en_NZ
dc.languageengen_NZ
dc.publisherMassachusetts Medical Societyen_NZ
dc.relation.urihttps://www.nejm.org/doi/10.1056/NEJMoa1804492en_NZ
dc.rightsCopyright � 2018 Massachusetts Medical Society. This Author Final Manuscript is licensed for use under the CC BY license.en_NZ
dc.subjectStroke; Lifetime risk; Preventionen_NZ
dc.titleGlobal, Regional, and Country-specific Lifetime Risks of Stroke, 1990 and 2016en_NZ
dc.typeJournal Article
dc.rights.accessrightsOpenAccessen_NZ
dc.identifier.doi10.1056/NEJMoa1804492en_NZ
aut.relation.endpage2437
aut.relation.issue25en_NZ
aut.relation.startpage2429
aut.relation.volume379en_NZ
pubs.elements-id351131
aut.relation.journalNew England Journal of Medicineen_NZ


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