Fluorescent Photolabile Caging Groups with Tuneable Sub-Cellular Localisation

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aut.embargoNoen_NZ
aut.filerelease.date2025-06-10
aut.thirdpc.containsNoen_NZ
dc.contributor.advisorFleming, Cassandra
dc.contributor.authorCarmichael, Cailin Annie
dc.date.accessioned2022-06-09T22:53:36Z
dc.date.available2022-06-09T22:53:36Z
dc.date.copyright2022
dc.date.issued2022
dc.date.updated2022-06-09T21:15:35Z
dc.description.abstractPhotopharmacology is a rapidly emerging area of interest in the context of drug delivery. With the potential to dictate when and where a drug is active within a biological system, the combination of photopharmacology with targeted drug delivery could offer significant improvements for drug delivery by reducing toxicities and increasing bioavailability. Photocaging groups offer the ability to combine these two areas, with the photocage inhibiting the bioactivity of the drug until it is released, as well as providing a structure to which organelle-targeting ligands can be attached. This project aims to develop novel photocaging groups that also function as organelle-targeted drug delivery systems. Coumarin-derived photocages were selected for this project due to their fluorescent properties, non-toxic nature in biological systems, and ability to decage at wavelengths higher than 400 nm. To date, a novel coumarin-derived caging group containing a suitable synthetic handle to which organelle targeting ligands can be introduced has been developed.en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/15211
dc.language.isoenen_NZ
dc.publisherAuckland University of Technology
dc.rights.accessrightsOpenAccess
dc.titleFluorescent Photolabile Caging Groups with Tuneable Sub-Cellular Localisationen_NZ
dc.typeDissertationen_NZ
thesis.degree.grantorAuckland University of Technology
thesis.degree.levelHonours
thesis.degree.nameBachelor of Advanced Science (Honours)en_NZ
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