aut.relation.issue	9	en_NZ
aut.relation.journal	Diabetic Medicine	en_NZ
aut.relation.volume	25	en_NZ
dc.contributor.author	Rush, E	en_NZ
dc.contributor.author	Crook, N	en_NZ
dc.contributor.author	Simmons, D	en_NZ
dc.date.accessioned	2021-06-04T01:57:50Z
dc.date.available	2021-06-04T01:57:50Z
dc.date.copyright	2008	en_NZ
dc.date.issued	2008	en_NZ
dc.description.abstract	Aim To determine the utility of finger-prick point-of-care testing (POCT) of blood glucose for the detection of dysglycaemia. Methods A fasting POCT and an oral glucose tolerance test (OGTT) with laboratory assays were performed as part of the baseline screening for 5309 participants enrolled in the Te Wai o Rona Diabetes Prevention Strategy. Participants were aged 46 ± 19 years with no self-reported diabetes. Dysglycaemia, including diabetes, was defined using World Health Organization criteria. Agreement between the two fasting plasma glucose measurements and their screening properties (with sensitivity and specificity for cut points) were compared using receiver operator characteristic analysis. Results A total of 3225 participants had both capillary and venous fasting blood sampled within 30 min and then underwent OGTT. New diabetes was found in 161 participants (5.0%) and pre-diabetes in 414 [impaired glucose tolerance 299 (9.3%), impaired fasting glucose 115 (3.6%)]. The mean difference in capillary and venous measures was 0.02 mmol/l (95% confidence interval −0.04 to +0.01; limits of agreement –1.37 to 1.33 mmol/l). Capillary POCT was a poorer predictor of dysglycaemia and impaired glucose tolerance and new diabetes (area under curve 0.76 and 0.71) than venous laboratory analysis (area under curve 0.87 and 0.81 respectively). Optimal screening criteria were best at a venous glucose of 5.4 mmol/l; 77% sensitivity/specificity. Conclusions POCT significantly underestimated the true blood glucose at diagnostic levels for diabetes. POCT cannot be recommended as a means of screening for or diagnosing diabetes or pre-diabetes.
dc.identifier.citation	Diabetic Medicine, 25(9), 1070-1075.
dc.identifier.doi	10.1111/j.1464-5491.2008.02526.x
dc.identifier.roid	7652	en_NZ
dc.identifier.uri	https://hdl.handle.net/10292/14242
dc.publisher	John Wiley & Sons
dc.relation.uri	https://onlinelibrary.wiley.com/doi/full/10.1111/j.1464-5491.2008.02526.x	en_NZ
dc.rights	Copyright © 2008 John Wiley & Sons. All rights reserved. Authors retain the right to place his/her pre-publication version of the work on a personal website or institutional repository. This article may not exactly replicate the final version published in (please see citation) as it is not a copy of this record. An electronic version of this article can be found online at: (Please see Publisher’s Version).
dc.rights.accessrights	OpenAccess	en_NZ
dc.subject	Point of Care; Dysglycemia; Detection; Prediabetes; Indigenous health; Sensitivity; Specificity
dc.title	Point-of-care Testing As a Tool for Screening for Diabetes and Pre-diabetes	en_NZ
dc.type	Journal Article
pubs.elements-id	14745
pubs.organisational-data	/AUT
pubs.organisational-data	/AUT/Faculty of Health & Environmental Science
pubs.organisational-data	/AUT/Faculty of Health & Environmental Science/School of Sport & Recreation
pubs.organisational-data	/AUT/Faculty of Health & Environmental Science/School of Sport & Recreation/Physical Activity, Nutrition & the Outdoors Department
pubs.organisational-data	/AUT/PBRF
pubs.organisational-data	/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data	/AUT/PBRF/PBRF Health and Environmental Sciences/HS Sports & Recreation 2018 PBRF

Point-of-care Testing As a Tool for Screening for Diabetes and Pre-diabetes

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