This research examines how to integrate information system (IS) with business by aligning IS strategy with business strategy. The existing literature postulates a variety of antecedents that can be used to achieve business-IT alignment. Yet, the question of how to accomplish alignment in an uncertain environment remains largely unanswered. In fact much of the research conducted in this regard has employed an approach, which examines the impact of antecedents on alignment. They fail to examine how environmental uncertainty affects the alignment and the capabilities of antecedents to achieve alignment in an uncertain environment. Hence, this research proposes a conceptual model to assess the way antecedents can contribute to aligning IS strategy with business strategy in an uncertain environment. The conceptual model will be validated through a survey of Sri Lankan organizations. Findings tied to this initiative will provide important contributions to both research and practice.