Investigation Into Nasal Saline Irrigation Within a Healthy Human Nose

aut.embargoNoen_NZ
aut.filerelease.date2022-06-24
aut.thirdpc.containsNoen_NZ
dc.contributor.advisorWhite, David
dc.contributor.advisorNates, Roy
dc.contributor.advisorBartley, Jim
dc.contributor.authorSalati, Hana
dc.date.accessioned2019-06-24T23:59:22Z
dc.date.available2019-06-24T23:59:22Z
dc.date.copyright2019
dc.date.issued2019
dc.date.updated2019-06-24T03:15:38Z
dc.description.abstractNasal saline irrigation is a therapy that bathes the nasal mucosa with a liquid saline solution to treat inflammatory nasal and paranasal disease or manage post nasal and sinus surgery recovery. Saline irrigation is thought to improve nasal airway surface liquid (ASL) hydration and mucociliary transport. Also, it has previously shown that mechanical factors, including cyclic pressure and wall shear stresses distribution, may positively influence mucociliary clearance. A detailed saline flow analysis within the nasal cavities and maxillary sinuses during saline irrigation in various head positions and side directions, in the presence of a nasal cycle geometry, has not previously been investigated. Knowledge of the saline flow fields within the nasal cavities and maxillary sinuses during nasal saline irrigation is essential to an understanding of how different head positions and side directions affect the targeted delivery site, and whether the irrigant has the potential to stimulate the mucociliary functions at different regions of the nasal cavities and maxillary sinuses. In this thesis the distribution and pressure of the irrigant, and the mucosal wall shear stress in the human nasal cavities and maxillary sinuses, have been mapped during nasal saline irrigation using computational fluid dynamics (CFD) simulations in the presence of the nasal cycle at four different head positions: Mygind (lying with head back), 90° (tilting the head sideways at 90°), head back (head is oriented 45° upward from the ground), and head forward (head is inclined downwards at 45° to the ground). Particle image velocimetry (PIV) measurements have been applied to confirm the validity of the numerical methodology used in this study. Close agreement was found between numerical and experimental results performed under identical conditions and geometries. New findings of this study have shown that saline irrigation at different head positions and side directions results in different saline distribution and saline pressure and mucosal wall shear stress distribution. The findings of this study will allow both clinicians and patients to make better-informed decisions on optimal irrigation techniques to better realise the full benefits of this form of treatment.en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/12583
dc.language.isoenen_NZ
dc.publisherAuckland University of Technology
dc.rights.accessrightsOpenAccess
dc.subjectNasal cavityen_NZ
dc.subjectHead positionsen_NZ
dc.subjectCFDen_NZ
dc.subjectPIVen_NZ
dc.subjectMaxillary Sinusesen_NZ
dc.subjectNasal saline irrigationen_NZ
dc.subjectCRSen_NZ
dc.subjectMRIen_NZ
dc.subjectNasal cycleen_NZ
dc.titleInvestigation Into Nasal Saline Irrigation Within a Healthy Human Noseen_NZ
dc.typeThesisen_NZ
thesis.degree.grantorAuckland University of Technology
thesis.degree.levelDoctoral Theses
thesis.degree.nameDoctor of Philosophyen_NZ
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