Specialization of Amygdala Subregions in Emotion Processing

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aut.relation.issue5
aut.relation.journalHuman Brain Mapping
aut.relation.volume45
dc.contributor.authorLabuschagne, Izelle
dc.contributor.authorDominguez, Juan F
dc.contributor.authorGrace, Sally
dc.contributor.authorMizzi, Simone
dc.contributor.authorHenry, Julie D
dc.contributor.authorPeters, Craig
dc.contributor.authorRabinak, Christine A
dc.contributor.authorSinclair, Erin
dc.contributor.authorLorenzetti, Valentina
dc.contributor.authorTerrett, Gill
dc.contributor.authorRendell, Peter G
dc.contributor.authorPedersen, Mangor
dc.contributor.authorHocking, Darren R
dc.contributor.authorHeinrichs, Markus
dc.date.accessioned2024-04-23T00:08:04Z
dc.date.available2024-04-23T00:08:04Z
dc.date.issued2024-04-09
dc.description.abstractThe amygdala is important for human fear processing. However, recent research has failed to reveal specificity, with evidence that the amygdala also responds to other emotions. A more nuanced understanding of the amygdala's role in emotion processing, particularly relating to fear, is needed given the importance of effective emotional functioning for everyday function and mental health. We studied 86 healthy participants (44 females), aged 18–49 (mean 26.12 ± 6.6) years, who underwent multiband functional magnetic resonance imaging. We specifically examined the reactivity of four amygdala subregions (using regions of interest analysis) and related brain connectivity networks (using generalized psycho‐physiological interaction) to fear, angry, and happy facial stimuli using an emotional face‐matching task. All amygdala subregions responded to all stimuli (<jats:italic>p</jats:italic>‐FDR &lt; .05), with this reactivity strongly driven by the superficial and centromedial amygdala (<jats:italic>p</jats:italic>‐FDR &lt; .001). Yet amygdala subregions selectively showed strong functional connectivity with other occipitotemporal and inferior frontal brain regions with particular sensitivity to fear recognition and strongly driven by the basolateral amygdala (<jats:italic>p</jats:italic>‐FDR &lt; .05). These findings suggest that amygdala specialization to fear may not be reflected in its local activity but in its connectivity with other brain regions within a specific face‐processing network.
dc.identifier.citationHuman Brain Mapping, ISSN: 1065-9471 (Print); 1097-0193 (Online), Wiley, 45(5). doi: 10.1002/hbm.26673
dc.identifier.doi10.1002/hbm.26673
dc.identifier.issn1065-9471
dc.identifier.issn1097-0193
dc.identifier.urihttp://hdl.handle.net/10292/17448
dc.languageen
dc.publisherWiley
dc.relation.urihttps://onlinelibrary.wiley.com/doi/10.1002/hbm.26673
dc.rights© 2024 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.rights.accessrightsOpenAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject1109 Neurosciences
dc.subject1702 Cognitive Sciences
dc.subjectExperimental Psychology
dc.subject3209 Neurosciences
dc.subject5202 Biological psychology
dc.subject5204 Cognitive and computational psychology
dc.titleSpecialization of Amygdala Subregions in Emotion Processing
dc.typeJournal Article
pubs.elements-id544467
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