Manipulation of Dysfunctional Spinal Joints Affects Sensorimotor Integration in the Pre-fontal Cortex: A Brain Source Localization Study

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dc.contributor.authorLelic, Den_NZ
dc.contributor.authorNiazi, IKen_NZ
dc.contributor.authorHolt, Ken_NZ
dc.contributor.authorJochumsen, Men_NZ
dc.contributor.authorDremstrup, Ken_NZ
dc.contributor.authorYielder, Pen_NZ
dc.contributor.authorMurphy, Ben_NZ
dc.contributor.authorDrewes, AMen_NZ
dc.contributor.authorHaavik, Hen_NZ
dc.date.accessioned2017-07-26T00:15:38Z
dc.date.available2017-07-26T00:15:38Z
dc.date.copyright2016-01-28en_NZ
dc.date.issued2016-01-28en_NZ
dc.description.abstractObjectives. Studies have shown decreases in N30 somatosensory evoked potential (SEP) peak amplitudes following spinal manipulation (SM) of dysfunctional segments in subclinical pain (SCP) populations. This study sought to verify these findings and to investigate underlying brain sources that may be responsible for such changes. Methods. Nineteen SCP volunteers attended two experimental sessions, SM and control in random order. SEPs from 62-channel EEG cap were recorded following median nerve stimulation (1000 stimuli at 2.3 Hz) before and after either intervention. Peak-to-peak amplitude and latency analysis was completed for different SEPs peak. Dipolar models of underlying brain sources were built by using the brain electrical source analysis. Twoway repeated measures ANOVA was used to assessed differences in N30 amplitudes, dipole locations, and dipole strengths. Results. SM decreased the N30 amplitude by 16.9 ± 31.3% (𝑃 = 0.02), while no differences were seen following the control intervention (𝑃 = 0.4). Brain source modeling revealed a 4-source model but only the prefrontal source showed reduced activity by 20.2 ± 12.2% (𝑃 = 0.03) following SM. Conclusion. A single session of spinal manipulation of dysfunctional segments in subclinical pain patients alters somatosensory processing at the cortical level, particularly within the prefrontal cortex.
dc.identifier.citationNeural Plasticity. Volume 2016 (2016), Article ID 3704964, 9 pages, doi: 10.1155/2016/3704964
dc.identifier.doi10.1155/2016/3704964en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/10685
dc.publisherHindawien_NZ
dc.relation.urihttps://www.hindawi.com/journals/np/2016/3704964/en_NZ
dc.rightsCopyright © 2016 Dina Lelic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.accessrightsOpenAccessen_NZ
dc.titleManipulation of Dysfunctional Spinal Joints Affects Sensorimotor Integration in the Pre-fontal Cortex: A Brain Source Localization Studyen_NZ
dc.typeJournal Article
pubs.elements-id194108
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Clinical Sciences
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