Health-related Quality of Life in Gout in Primary Care: Baseline Findings From a Cohort Study
aut.relation.journal | Seminars in Arthritis and Rheumatism | en_NZ |
aut.researcher | Rome, Keith | |
dc.contributor.author | Chandratre, P | en_NZ |
dc.contributor.author | Mallen, C | en_NZ |
dc.contributor.author | Richardson, J | en_NZ |
dc.contributor.author | Muller, S | en_NZ |
dc.contributor.author | Rome, K | en_NZ |
dc.contributor.author | Blagojevic-Bucknall, M | en_NZ |
dc.contributor.author | Roddy, E | en_NZ |
dc.date.accessioned | 2018-01-09T22:01:01Z | |
dc.date.available | 2018-01-09T22:01:01Z | |
dc.date.copyright | 2018-01-09 | en_NZ |
dc.date.issued | 2018-01-09 | en_NZ |
dc.description.abstract | Objectives To examine gout-related, comorbid and sociodemographic characteristics associated with generic and disease-specific Health-Related Quality Of Life (HRQOL) in gout. Methods Adults with gout from 20 general practices were mailed a questionnaire containing the Health Assessment Questionnaire-Disability Index (HAQ-DI), Short-Form-36 Physical Function subscale (PF-10), Gout Impact Scale (GIS), and questions about gout-specific, comorbid and sociodemographic characteristics. Variables associated with HRQOL were examined using multivariable linear regression models. Results 1184 completed questionnaires were received (response 65.9%). Worse generic and gout-specific HRQOL was associated with frequent gout attacks (≥5 attacks PF-10 β=−4.90, HAQ-DI β=0.14, GIS subscales β=8.94 to 33.26), current attack (HAQ-DI β=0.15, GIS β=−1.94 to 18.89), oligo/polyarticular attacks (HAQ-DI β=0.11, GIS β=0.78 to 7.86), body pain (PF-10 β=−10.68, HAQ-DI β=0.29, GIS β=2.61 to 11.89), anxiety (PF-10 β=−1.81, HAQ-DI β=0.06, GIS β=0.38 to 1.70), depression (PF-10 β=−1.98, HAQ-DI β=0.06, GIS 0.42 to 1.47) and alcohol non-consumption (PF-10 β=−16.10, HAQ-DI β=0.45, GIS β=4.94). Gout-specific HRQOL was better in Caucasians than non-Caucasians (GIS β=−13.05,−13.48). Poorer generic HRQOL was associated with diabetes mellitus (PF-10 β=−4.33, HAQ-DI β=0.14), stroke (PF-10 β=−12.21, HAQ-DI β=0.37), renal failure (PF-10 β=−9.43, HAQ-DI β=0.21), myocardial infarction (HAQ-DI β=0.17), female gender (PF-10 β=−17.26, HAQ-DI β=0.43), deprivation (PF-10 β=−7.80, HAQ-DI β=0.19), and body mass index≥35 kg/m2 (PF-10 β=−6.10, HAQ-DI β=0.21). Conclusions HRQOL in gout is impaired by gout-specific, comorbid, and sociodemographic characteristics, highlighting the importance of comorbidity screening and early urate-lowering therapy. Both gout-specific and generic questionnaires identify the impact of disease-specific features on HRQOL but studies focusing on comorbidity should include generic instruments. | |
dc.identifier.doi | 10.1016/j.semarthrit.2017.12.005 | |
dc.identifier.issn | 0049-0172 | en_NZ |
dc.identifier.uri | https://hdl.handle.net/10292/11061 | |
dc.publisher | Elsevier | en_NZ |
dc.relation.uri | https://www.sciencedirect.com/science/article/pii/S0049017217306054 | |
dc.rights | Copyright © 2018 Elsevier Ltd. All rights reserved. This is the author’s version of a work that was accepted for publication in (see Citation). Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. The definitive version was published in (see Citation). The original publication is available at (see Publisher's Version). | |
dc.rights.accessrights | OpenAccess | en_NZ |
dc.subject | Gout; Health Related Quality of Life; Primary care; Comorbidity | |
dc.title | Health-related Quality of Life in Gout in Primary Care: Baseline Findings From a Cohort Study | en_NZ |
dc.type | Journal Article | |
pubs.elements-id | 323080 | |
pubs.organisational-data | /AUT | |
pubs.organisational-data | /AUT/Health & Environmental Science | |
pubs.organisational-data | /AUT/Health & Environmental Science/Clinical Sciences | |
pubs.organisational-data | /AUT/PBRF | |
pubs.organisational-data | /AUT/PBRF/PBRF Health and Environmental Sciences | |
pubs.organisational-data | /AUT/PBRF/PBRF Health and Environmental Sciences/HH Clinical Sciences 2018 PBRF |
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