Gout on CT of the Feet: A Symmetric Arthropathy

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aut.researcherRome, Keith
dc.contributor.authorDoyle, AJen_NZ
dc.contributor.authorDalbeth, Nen_NZ
dc.contributor.authorMcQueen, Fen_NZ
dc.contributor.authorBoyer, Len_NZ
dc.contributor.authorDong, Jen_NZ
dc.contributor.authorRome, Ken_NZ
dc.contributor.authorFrecklington, Men_NZ
dc.date.accessioned2016-09-22T01:52:06Z
dc.date.available2016-09-22T01:52:06Z
dc.date.copyright2016-05-09en_NZ
dc.date.issued2016-05-09en_NZ
dc.description.abstractIntroduction The aim of this study was to assess the distribution of bone erosions in the feet of patients with gout using CT and thereby to test the hypothesis that gout is an asymmetric arthropathy. Methods CT scans of both feet were obtained from 25 patients with chronic gout. CT scans were scored for bone erosion using a semi-quantitative method based on the rheumatoid arthritis MRI scoring system (RAMRIS). CT bone erosion was assessed at 22 bones in each foot (total 1,100 bones) by two independent radiologists. Symmetry was assessed by two methods: (i) comparing right and left foot scores for each patient; and (ii) calculating the proportion of paired joints with or without erosions. Results Observer agreement was excellent (intra-class correlation coefficient 0.92). In the group overall, the difference in scores between the feet was not significant (Student's t-test Pā€‰=ā€‰0.8). In 17 of 25 patients, the difference in erosion scores between the two feet was less than the inter-observer difference. In 24 of 25 patients, the proportion of paired joints was greater than 0.5, indicating symmetric disease. Conclusions Erosive disease from gout is, in fact, a symmetric process in our patient group. This finding is contrary to the established view of gout as an asymmetric arthritis and lends new insight into the behaviour of this common disease.
dc.identifier.citationJournal of Medical Imaging and Radiation Oncology, 60: 54ā€“58. doi:10.1111/1754-9485.12419en_NZ
dc.identifier.doi10.1111/1754-9485.12419
dc.identifier.issn1754-9485en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/10051
dc.publisherJohn Wiley & Sons
dc.rightsThis is the peer reviewed version of the following article: Doyle, A. J., Dalbeth, N., McQueen, F., Boyer, L., Dong, J., Rome, K. and Frecklington, M. (2016), Gout on CT of the feet: A symmetric arthropathy. Journal of Medical Imaging and Radiation Oncology, 60: 54ā€“58., which has been published in final form at doi:10.1111/1754-9485.12419. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectMusculoskeletal imaging; Musculoskeletal
dc.titleGout on CT of the Feet: A Symmetric Arthropathyen_NZ
dc.typeJournal Article
pubs.elements-id206894
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Clinical Sciences
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