Quadriceps Arthrogenic Muscle Inhibition: The Effects of Experimental Knee Joint Effusion on Motor Cortex Excitability

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aut.relation.articlenumber502en_NZ
aut.relation.journalArthritis Research and Therapyen_NZ
aut.relation.volume16en_NZ
aut.researcherRice, David
dc.contributor.authorRice, DAen_NZ
dc.contributor.authorMcNair, PJen_NZ
dc.contributor.authorLewis, GNen_NZ
dc.contributor.authorDalbeth, Nen_NZ
dc.date.accessioned2020-03-02T23:30:47Z
dc.date.available2020-03-02T23:30:47Z
dc.date.copyright2014en_NZ
dc.date.issued2014en_NZ
dc.description.abstractIntroduction Marked weakness of the quadriceps muscles is typically observed following injury, surgery or pathology affecting the knee joint. This is partly due to ongoing neural inhibition that prevents the central nervous system from fully activating the quadriceps, a process known as arthrogenic muscle inhibition (AMI). This study aimed to further investigate the mechanisms underlying AMI by exploring the effects of experimental knee joint effusion on quadriceps corticomotor and intracortical excitability. Methods Seventeen healthy volunteers participated in this study. Transcranial magnetic stimulation was used to measure quadriceps motor evoked potential area, short-interval intracortical inhibition, intracortical facilitation and cortical silent period duration before and after experimental knee joint effusion. Joint effusion was induced by the intraarticular infusion of dextrose saline into the knee. Results There was a significant increase in quadriceps motor evoked potential area following joint infusion, both at rest (P = 0.01) and during voluntary muscle contraction (P = 0.02). Cortical silent period duration was significantly reduced following joint infusion (P = 0.02). There were no changes in short interval intracortical inhibition or intracortical facilitation over time (all P > 0.05). Conclusions The results of this study provide no evidence for a supraspinal contribution to quadriceps AMI. Paradoxically, but consistent with previous observations in patients with chronic knee joint pathology, quadriceps corticomotor excitability increased after experimental knee joint effusion. The increase in quadriceps corticomotor excitability may be at least partly mediated by a decrease in gamma-aminobutyric acid (GABA)-ergic inhibition within the motor cortex.
dc.identifier.citationArthritis Research & Therapy, 16(6), 502.
dc.identifier.doi10.1186/s13075-014-0502-4en_NZ
dc.identifier.issn1478-6354en_NZ
dc.identifier.issn1478-6362en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/13175
dc.publisherBioMed Centralen_NZ
dc.relation.urihttps://arthritis-research.biomedcentral.com/articles/10.1186/s13075-014-0502-4
dc.rights© 2014 Rice et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.rights.accessrightsOpenAccessen_NZ
dc.titleQuadriceps Arthrogenic Muscle Inhibition: The Effects of Experimental Knee Joint Effusion on Motor Cortex Excitabilityen_NZ
dc.typeJournal Article
pubs.elements-id173771
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Clinical Sciences
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HH Clinical Sciences 2018 PBRF
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