Roth, GAMensah, GAAbd-Allah, FFuster, VMurray, CJLAbate, YHAbbasian, MAbdollahi, AAbdollahi, MAbdulah, DMAbdullahi, AAbebe, AMAbedi, AAbedi, AAbiodun, OOAli, HAAbu-Gharbieh, EAbu-Rmeileh, NMEAburuz, SAbushouk, AIAbu-Zaid, AAdane, TDAdderley, NJAdebayo, OMAden, BAdeyeoluwa, TEAdeyomoye, OISakilah Adnani, QEAfrashteh, FAfyouni, SAfzal, SAgasthi, PAgodi, AAguilera Arriagada, CEAgyemang-Duah, WAhinkorah, BOAhmad, AAhmad, DAhmad, FAhmad, MMAhmed, AAhmed, HAhmed, MBAhmed, SAAjami, MAkinosoglou, KAla, MAli AL-Ahdal, TMAlalalmeh, SOAl-Aly, ZAlam, NAl-amer, RMAlashi, AAlbashtawy, MAlBataineh, MTAlema, HBAlemi, SAlemu, YMSaeed Al-Gheethi, AAAlhabib, KFNaji Alhalaiqa, FAAli, MUAli, Rpursuing, PDShujait Ali, SSAlicandro, GAlikhani, RAljunid, SMAlla, FAlmahmeed, WAl-Marwani, SAlonso, JAl-Raddadi, RMAlvi, FJAlvis-Guzman, NAlvis-Zakzuk, NJAlwafi, HAly, HAmegbor, PMAmin, TTAmindarolzarbi, AAmini-Rarani, MAmiri, SAmmirati, EAnand, TAncuceanu, RAnderlini, DAnil, AAnsari, GAnyanwu, PEAnyasodor, AECarace Apostol, GLArabloo, JArafat, MAravkin, AYAremu, OArmocida, BÄrnlöv, JArowosegbe, OOArtamonov, AA2026-02-252026-02-252023-12-11Journal of the American College of Cardiology, ISSN: 0735-1097 (Print); 1558-3597 (Online), Elsevier BV, 82(25), 2350-2473. doi: 10.1016/j.jacc.2023.11.0070735-10971558-3597http://hdl.handle.net/10292/20680Age-standardized CVD mortality rates by region ranged from 73.6 per 100,000 in High income Asia Pacific to 432.3 per 100,000 in Eastern Europe in 2022. Global CVD mortality decreased by 34.9% from 1990 to 2022. Ischemic heart disease had the highest global age-standardized DALYs of all diseases at 2,275.9 per 100,000. Intracerebral hemorrhage and ischemic stroke were the next highest CVD causes for age-standardized DALYs. Age-standardized CVD prevalence ranged from 5,881.0 per 100,000 in South Asia to 11,342.6 per 100,000 in Central Asia. High systolic blood pressure accounted for the largest number of attributable age-standardized CVD DALYs at 2,564.9 per 100,000 globally. Of all risks, household air pollution from solid fuels had the largest change in attributable age-standardized DALYs from 1990 to 2022 with a 65.1% decrease.This is the Author's Accepted Manuscript of an article published in the Journal of the American College of Cardiology © 2023 American College of Cardiology Foundation. The Version of Record is available at DOI: 10.1016/j.jacc.2023.11.007Global Burden of Cardiovascular Diseases and Risks Collaborators32 Biomedical and Clinical Sciences3201 Cardiovascular Medicine and Haematology1102 Cardiorespiratory Medicine and Haematology1117 Public Health and Health ServicesCardiovascular System & Hematology3201 Cardiovascular medicine and haematologyHumansCardiovascular DiseasesRisk FactorsEnvironmental ExposureGlobal HealthQuality-Adjusted Life YearsHumansCardiovascular DiseasesRisk FactorsEnvironmental ExposureQuality-Adjusted Life YearsGlobal HealthHumansCardiovascular DiseasesRisk FactorsEnvironmental ExposureGlobal HealthQuality-Adjusted Life YearsJournal ArticleOpenAccess10.1016/j.jacc.2023.11.007