Tabi-Amponsah, Adwoa DansoaStamp, Lisa KHorne, AnneDrake, JillStewart, SarahGamble, GregPetrie, Keith JDalbeth, Nicola2026-03-022026-03-022024-08-01Journal of Rheumatology, ISSN: 0315-162X (Print); 1499-2752 (Online), 51(11), 1135-1140. doi: 10.3899/jrheum.2024-04000315-162X1499-2752http://hdl.handle.net/10292/20705OBJECTIVE: To investigate the effect of colchicine prophylaxis on gout remission when commencing urate lowering therapy (ULT), and illness perceptions of people in remission, using two definitions of gout remission. METHODS: Data from a 12-month double-blind placebo-controlled trial of 200 people with gout commencing allopurinol were analyzed. Participants were randomly assigned to prophylaxis with 0.5mg daily colchicine or placebo for six months, followed by six months of additional follow-up. Gout remission was assessed using the 2016 preliminary definition or simplified definition without patient reported outcomes. Illness perceptions were assessed using a gout-specific brief illness perception questionnaire (BIPQ). RESULTS: In the first six months, few participants were in remission according to either the 2016 preliminary definition (3% for colchicine and 4% for placebo) or the simplified definition (7% for colchicine and 12% for placebo). In the second six months, after study drug (colchicine or placebo) discontinuation, fewer participants in the colchicine group than in the placebo group were in remission according to the 2016 preliminary definition (4% vs. 14%, p=0.03), and the simplified definition (14% vs 28%, p=0.02). Participants fulfilling remission using either definition had more favorable perceptions about their gout symptoms and illness concerns, as well as consequences, when using the simplified definition. CONCLUSION: Using either definition, six months of colchicine prophylaxis when initiating ULT does not provide an advantage in the fulfilment of gout remission. People fulfilling either definition report fewer symptoms, lower concern about their gout, and when using the simplified definition, are less affected by gout.This is the Author's Accepted Manuscript of an article published in the Journal of Rheumatology © 2024 by The Journal of Rheumatology Publishing Co. Ltd. The Version of Record is available at DOI: 10.3899/jrheum.2024-0400colchicinegoutremission32 Biomedical and Clinical Sciences3202 Clinical SciencesClinical Trials and Supportive ActivitiesClinical Research6.1 PharmaceuticalsInflammatory and immune system1103 Clinical Sciences1107 Immunology1117 Public Health and Health ServicesArthritis & Rheumatology3202 Clinical sciences3204 ImmunologyHumansColchicineAllopurinolGoutGout SuppressantsMaleFemaleMiddle AgedDouble-Blind MethodAgedRemission InductionTreatment OutcomeAdultHumansGoutColchicineAllopurinolGout SuppressantsTreatment OutcomeRemission InductionDouble-Blind MethodAdultAgedMiddle AgedFemaleMaleJournal ArticleOpenAccess10.3899/jrheum.2024-0400