Lowe, MelanieSallis, James FSalvo, DeborahCerin, EsterBoeing, GeoffHiggs, CarlLiu, ShiqinHinckson, EricaAdlakha, DeeptiArundel, JonathanMoudon, Anne VernezResendiz, EugenGiles-Corti, Billie2024-12-092024-12-092022-10-17Journal of City Climate Policy and Economy, ISSN: 2816-7414 (Print), University of Toronto Press Inc. (UTPress), 1(1), 111-123. doi: 10.3138/jccpe-2022.1.1.00082816-7414http://hdl.handle.net/10292/18443Creating healthy and sustainable cities should be a global priority. Some cities prioritize 15-minute cities as a planning approach with co-benefits for health, climate change mitigation, equity, and economic recovery from COVID-19. Yet, as our recent Lancet Global Health series on “Urban Design, Transport, and Health” showed, many cities have a long way to go to achieve this vision. This policy guideline summarizes the main findings of the series, which assessed health and sustainability indicators for 25 cities in 19 countries. We then outline steps governments can take to strengthen policy frameworks and deliver more healthy, equitable, and sustainable built environments. </jats:p><jats:p> The Lancet Global Health series provided clear evidence that cities need to transform urban governance to enable integrated planning for health and sustainability and commit to policy implementation. Evidence-informed indicators should be used to benchmark and monitor progress. Cities need policy frameworks that are comprehensive and consistent with evidence, with measurable policy targets to support implementation and accountability. The series provided evidence-informed thresholds for some key urban design and transport features, which can be embedded as policy targets. Policies and interventions must prioritize identifying and reducing inequities in access to health-supportive environments. Governments should also invest in open data and promote citizen-science programmes, to support indicator development and research for public benefit. We provide tools to replicate our indicators and an invitation to join our 1000 Cities Challenge via the Global Observatory of Healthy and Sustainable Cities.The Journal of City Climate Policy and Economy (JCCPE) is available through a Subscribe to Open model in an effort to achieve the goals of broad dissemination of content valued by scholars and researchers.33 Built Environment and Design4206 Public Health42 Health Sciences44 Human Society4407 Policy and Administration3304 Urban and Regional PlanningInfectious Diseases8.3 Policy, ethics, and research governanceGeneric health relevance11 Sustainable Cities and CommunitiesJournal ArticleOpenAccess10.3138/jccpe-2022.1.1.0008