Kumar, HGreen, RCornfeld, DMCondron, PEmsden, TElsayed, AZhao, DGilbert, KNash, MPClark, ARTawhai, MHBurrowes, KMurphy, RTayebi, MMcGeown, JKwon, EShim, VWang, AChoisne, JCarman, LBesier, THandsfield, GBabarenda Gamage, TPShen, JMaso Talou, GSafaei, SMaller, JJTaylor, DPotter, LHoldsworth, SJWilson, GA2023-05-152023-05-152023-03-10Frontiers in Physiology, ISSN: 1664-042X (Print); 1664-042X (Online), Frontiers Media SA, 14, 1104838-. doi: 10.3389/fphys.2023.11048381664-042X1664-042Xhttps://hdl.handle.net/10292/16134Our study methodology is motivated from three disparate needs: one, imaging studies have existed in silo and study organs but not across organ systems; two, there are gaps in our understanding of paediatric structure and function; three, lack of representative data in New Zealand. Our research aims to address these issues in part, through the combination of magnetic resonance imaging, advanced image processing algorithms and computational modelling. Our study demonstrated the need to take an organ-system approach and scan multiple organs on the same child. We have pilot tested an imaging protocol to be minimally disruptive to the children and demonstrated state-of-the-art image processing and personalized computational models using the imaging data. Our imaging protocol spans brain, lungs, heart, muscle, bones, abdominal and vascular systems. Our initial set of results demonstrated child-specific measurements on one dataset. This work is novel and interesting as we have run multiple computational physiology workflows to generate personalized computational models. Our proposed work is the first step towards achieving the integration of imaging and modelling improving our understanding of the human body in paediatric health and disease.http://creativecommons.org/licenses/by/4.0/MRI image analysischild health and developmentcomputational modellingneuroimage analysisradiology3101 Biochemistry and Cell Biology3208 Medical Physiology32 Biomedical and Clinical Sciences31 Biological SciencesBiomedical ImagingBioengineering1 Underpinning research1.1 Normal biological development and functioningGeneric health relevanceCardiovascular3 Good Health and Well Being0606 Physiology1116 Medical Physiology1701 Psychology3101 Biochemistry and cell biology3208 Medical physiologyJournal ArticleOpenAccess10.3389/fphys.2023.1104838