Gao, TianzhengMadanian, SamanehTempleton, JohnMerkin, Alexander2025-08-142025-08-142025Studies in Health Technology and Informatics, ISSN: 0926-9630 (Print); 0926-9630 (Online), IOS Press, 329, 1780-1781. doi: 10.3233/SHTI2512110926-96300926-9630http://hdl.handle.net/10292/19678This paper reviews the current research on Alzheimer's disease and the use of deep learning, particularly 3D-convolutional neural networks (3D-CNN), in analyzing brain images. It presents a predictive model based on MRI and clinical data from the ADNI dataset, showing that deep learning can improve diagnosis accuracy and sensitivity. We also discuss potential applications in biomarker discovery, disease progression prediction, and personalised treatment planning, highlighting the ability to identify sensitive features for early diagnosis.© 2025 The Authors. This article is published online with Open Access by IOS Press and distributed under the terms of the Creative Commons Attribution Non-Commercial License 4.0 (CC BY-NC 4.0).https://creativecommons.org/licenses/by-nc/4.0/deed.en_US3D-CNNDeep LearningDigital healthNeurodegenerative Diseases3D-CNNDeep LearningDigital healthNeurodegenerative Diseases46 Information and Computing Sciences4611 Machine LearningAlzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)Biomedical ImagingAgingBrain DisordersNeurosciencesBioengineeringAlzheimer's DiseaseDementiaNetworking and Information Technology R&D (NITRD)Acquired Cognitive ImpairmentPreventionNeurodegenerativeMachine Learning and Artificial Intelligence4.1 Discovery and preclinical testing of markers and technologies4.2 Evaluation of markers and technologiesNeurological3 Good Health and Well Being0807 Library and Information Studies1117 Public Health and Health ServicesMedical Informatics4203 Health services and systems4601 Applied computingAlzheimer DiseaseBrainDecision Support Systems, ClinicalDeep LearningHumansMagnetic Resonance ImagingNeural Networks, ComputerAlzheimer DiseaseHumansDecision Support Systems, ClinicalMagnetic Resonance ImagingDeep LearningNeural Networks, ComputerBrainBrainHumansAlzheimer DiseaseMagnetic Resonance ImagingDecision Support Systems, ClinicalDeep LearningNeural Networks, ComputerAlzheimer DiseaseHumansDecision Support Systems, ClinicalMagnetic Resonance ImagingDeep LearningNeural Networks, ComputerBrainJournal ArticleOpenAccess10.3233/SHTI251211