Pedersen, MangorPardoe, Heath Rde Weger, AntonHutchison, DonnaAbbott, David FVerspoor, KarinJackson, Graeme D2025-12-102025-12-102025-06-05Artificial Intelligence in Medicine, ISSN: 0933-3657 (Print); 1873-2860 (Online), Elsevier BV, 167, 103192-. doi: 10.1016/j.artmed.2025.1031920933-36571873-2860http://hdl.handle.net/10292/20365Artificial intelligence (AI) is a multidisciplinary scientific field that uses machines to solve real-world problems and predict outcomes. Despite the current enthusiasm about AI's potential as a clinical support tool, there is also a growing awareness and concern about the potentially harmful effects of AI. Because AI will likely impact expert-based decision-making in medicine, it is critical to consider the issues that AI raises in medical research. This paper outlines the AI guidelines of the Australian Epilepsy Project. This large-scale platform aims to democratise specialist care in epilepsy and use AI for clinical decision support based on prospective multimodal datasets (MRI, genetic, clinical, and cognitive data) from thousands of people with epilepsy. As AI develops rapidly, we focus on key areas of medical AI identified in the literature, including Trust, Responsibility and Safety. We believe AI is changing medicine, and we believe it is imperative to advance and update our AI guidelines adaptably while preparing for an era of augmented-intelligence-based medicine.© 2025 The Author(s). Published by Elsevier B.V. Note: This article is available under the Creative Commons CC-BY-NC license and permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.https://creativecommons.org/licenses/by/4.0/AEPAIArtificial IntelligenceAustralian Epilepsy ProjectEpilepsyEthicsAustralian Epilepsy Project Investigators46 Information and Computing Sciences4602 Artificial IntelligenceNeurosciencesBrain DisordersMachine Learning and Artificial IntelligenceBioengineeringPatient SafetyNetworking and Information Technology R&D (NITRD)NeurodegenerativeEpilepsyGeneric health relevanceNeurologicalMental health3 Good Health and Well Being08 Information and Computing Sciences09 EngineeringMedical Informatics32 Biomedical and clinical sciences42 Health sciences46 Information and computing sciencesArtificial IntelligenceEpilepsyHumansAustraliaDecision Support Systems, ClinicalClinical Decision-MakingHumansEpilepsyArtificial IntelligenceDecision Support Systems, ClinicalAustraliaClinical Decision-MakingArtificial IntelligenceEpilepsyHumansAustraliaDecision Support Systems, ClinicalClinical Decision-MakingJournal ArticleOpenAccess10.1016/j.artmed.2025.103192