Alao, JudeLau, KelvinWhite, DavidLee, KevinPuli'uvea, ChrisBartley, Jim2025-02-132025-02-132024-12-10Rangahau Aranga: AUT Graduate Review, ISSN: 2815-8202 (Print); 2815-8202 (Online), Auckland University of Technology (AUT) Library, 3(1). doi: 10.24135/rangahau-aranga.v3i2.2332815-82022815-8202http://hdl.handle.net/10292/18651This study aims to investigate the effects of acoustic therapy on the nasal microbiome, immune responses, and overall well-being in patients with allergic rhinitis (AR) and chronic rhinosinusitis (CRS). Utilizing the Goodair® NoseBuds, a low-cost acoustic device developed by the AUT BioDesign Lab, this research explores the potential of nasal mechanostimulation to increase endogenous nitric oxide production, improve nasal health, and alleviate AR and CRS symptoms. Participants will use the device twice daily over a four-week period, and the study will assess changes in nasal microbiome composition, inflammation markers, and patient-reported outcomes, such as symptom severity and quality of life. Data will be analysed through bioinformatics and statistical methods to identify correlations between acoustic therapy and immune or microbial changes. This research offers an innovative, non-pharmaceutical alternative for managing AR and CRS, with the potential to reduce reliance on traditional medications and improve patient outcomes.Copyright (c) 2024 Jude Alao, Kelvin Lau, David White, Kevin Lee, Chris Puli'uvea, Jim Bartley. Article text: Creative Commons License. This work is licensed under a Creative Commons Attribution 4.0 International License.https://creativecommons.org/licenses/by/4.0/32 Biomedical and Clinical Sciences3202 Clinical SciencesClinical ResearchClinical Trials and Supportive ActivitiesAllergic Rhinitis (Hay Fever)MicrobiomeRespiratoryJournal ArticleOpenAccess10.24135/rangahau-aranga.v3i2.233