Cervellini, MatteoFeller, DanielMaselli, FilippoRossettini, GiacomoCook, ChadTabrah, JuliaChauhan, Rohil VTaylor, AlanKerry, RogerYoung, IanDunning, JamesHutting, NathanMourad, Firas2025-03-182025-03-182025-03-04Journal of Manual and Manipulative Therapy, ISSN: 1066-9817 (Print); 2042-6186 (Online), Taylor and Francis Group, ahead-of-print(ahead-of-print), 1-17. doi: 10.1080/10669817.2025.24657281066-98172042-6186http://hdl.handle.net/10292/18871BACKGROUND: Degenerative cervical myelopathy (DCM) is a clinical syndrome characterized by a progressive compression of the spinal cord. DCM often looks like common symptoms of aging or bilateral carpal tunnel syndrome in its early stages, requiring careful differential diagnosis. Identifying DCM is a real challenge as no validated screening tools are available for making the DCM diagnosis. Potentially, individuals with DCM may experience misdiagnosis or substantial diagnostic delays, with an enhanced risk of irreversible neurological consequences if not promptly addressed. Despite the increasing prevalence, there is a lack of awareness about DCM among both the public and healthcare professionals. However, patients may seek physiotherapy to obtain a diagnosis or access treatment. METHODS: A comprehensive (non-systematic) review of the literature about DCM epidemiology, pathophysiology, clinical presentation, diagnostic methods, and management was conducted. RESULTS: A guide and essential knowledge to facilitate clinicians to understand DCM and to enhance clinical reasoning skills, performance and interpretation of the examination are provided. Interdisciplinary collaboration and optimal referral methods are also handled. CONCLUSION: The aim of this article is to summarize and enhance physiotherapists' essential knowledge of the differential diagnosis and management of patients with DCM.© 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.http://creativecommons.org/licenses/by-nc-nd/4.0/guideline adherenceintervertebral disc degenerationneck painPhysiotherapySpinal cord diseasesspinal cord compression4201 Allied Health and Rehabilitation Science32 Biomedical and Clinical Sciences3202 Clinical Sciences42 Health SciencesMinority HealthNeurosciencesRare DiseasesClinical ResearchHealth Disparities7.3 Management and decision making4.2 Evaluation of markers and technologiesNeurological1103 Clinical Sciences1106 Human Movement and Sports SciencesOrthopedics3202 Clinical sciences4207 Sports science and exerciseJournal ArticleOpenAccess10.1080/10669817.2025.2465728