Merkin, AlexanderAkinfieva, SofyaMedvedev, Oleg NKrishnamurthi, Rita VGutsaluk, AlexeyReips, Ulf-DietrichKuliev, RufatDinov, EvgenyNikiforov, IgorShamalov, NikolayShafran, PolinaPopova, LyudmilaBurenchev, DmitryFeigin, VL2023-02-212023-02-2120232023Cerebrovascular Diseases Extra, ISSN: 1664-5456 (Print); 1664-5456 (Online), Karger Publishers. doi: 10.1159/0005292771664-54561664-5456https://hdl.handle.net/10292/15884BACKGROUND: Early determination of COVID-19 severity and health outcomes could facilitate better treatment of patients. Different methods and tools have been developed for predicting outcomes of COVID-19, but they are difficult to use in routine clinical practice. METHODS: We conducted a prospective cohort study of inpatients aged 20-92 years, diagnosed with COVID-19 to determine whether their individual 5-year absolute risk of stroke at the time of hospital admission predicts the course of COVID-19 severity and mortality. The risk of stroke was determined by the Stroke Riskometer mobile application. RESULTS: We examined 385 patients hospitalised with COVID-19 (median age 61 years). The participants were categorised based on COVID-19 severity: 271 (70.4%) to the "Not severe" and 114 (29.6%) to the "Severe" groups. The median risk of stroke the next day after hospitalisation was significantly higher among patients in the Severe group (2.83 [95% CI 2.35-4.68]) vs the Not severe group (1.11 [95% CI 1.00-1.29]). The median risk of stroke and median systolic blood pressure (SBP) were significantly higher among non-survivors (12.04 [95% CI 2.73-21.19]) and (150 [95% CI 140-170]) vs survivors (1.31 [95% CI 1.14-1.52]), 134 [95% CI 130-135]), respectively. Those who spent more than 2.5 hours a week on physical activity were 3.1 times more likely to survive from COVID-19. Those who consumed more than one standard alcohol drink a day, or suffered with atrial fibrillation, or had poor memory were 2.5, 2.3, and 2.6 times more likely not to survive from COVID-19, respectively. CONCLUSIONS: High risk of stroke, physical inactivity, alcohol intake, high SBP, and atrial fibrillation are associated with severity and mortality of COVID-19. Our findings suggest that the Stroke Riskometer app could be used as a simple predictive tool of COVID-19 severity and mortality.https://creativecommons.org/licenses/by-nc/4.0/PreventionClinical ResearchCardiovascularStrokeBrain DisordersNeurosciencesRehabilitation4 Detection, screening and diagnosis4.2 Evaluation of markers and technologiesStrokeCardiovascular3 Good Health and Well BeingJournal ArticleOpenAccess10.1159/000529277