Li, ShaojunChong, BenjaminMehri-Kakavand, GhazalShi, CatherineTaylor, DeniseFowler, AllanBillinghurst, MarkHarvey, MonikaWang, Alan2026-05-212026-05-212026-05-04Neurorehabilitation and Neural Repair, ISSN: 1545-9683 (Print); 1552-6844 (Online), SAGE Publications, 15459683261445440-. doi: 10.1177/154596832614454401545-96831552-6844http://hdl.handle.net/10292/21168Background and Purpose: Augmented reality (AR) and artificial intelligence (AI) have been applied to the assessment and rehabilitation of post-stroke spatial neglect (SN). This study aims to evaluate the feasibility, effectiveness, degree of personalization, and ecological validity of AR, AI, and hybrid methods for SN assessment and rehabilitation. Methods: PubMed, Scopus, Web of Science, Embase, CINAHL, IEEE Xplore, and the ACM Digital Library were searched up to August 2025. Two reviewers independently screened articles, extracted data, and assessed risk of bias and outcome-level certainty. Results: Of 268 screened studies published between 2000 and 2025, 15 met the inclusion criteria, including 11 assessment studies (8 AI, 1 AR, and 2 hybrid) and 4 AR rehabilitation studies, involving 567 participants. AI assessment methods demonstrated high diagnostic accuracy (area under the curve (AUC) up to 0.95), and 1 AR assessment showed strong diagnostic accuracy (AUC = 0.89). Four AR rehabilitation studies reported acceptable feasibility, with 1 randomized controlled trial (RCT) showing improvements in several neglect outcomes. Ecological validity and personalization were generally very low, and the overall certainty of evidence ranged from low to very low. Conclusion: Current evidence for AR and AI SN assessment and rehabilitation methods remains insufficient to determine their feasibility, effectiveness, ecological validity, and degree of personalization, largely due to small sample sizes, methodological heterogeneity, and the limited number of RCTs. Future research should focus on developing standardized, scalable frameworks that integrate AR with adaptive AI models, and multicenter RCTs are required to confirm clinical efficacy and long-term functional outcomes© The Author(s) 2026. Creative Commons License (CC BY 4.0). This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).https://creativecommons.org/licenses/by/4.0/artificial intelligenceaugmented realityecological validitypersonalized neurorehabilitationspatial neglectstroke rehabilitation32 Biomedical and Clinical Sciences3209 NeurosciencesClinical Trials and Supportive ActivitiesRehabilitationNetworking and Information Technology R&D (NITRD)Clinical ResearchComparative Effectiveness ResearchBioengineeringMachine Learning and Artificial Intelligence1103 Clinical Sciences1109 Neurosciences1702 Cognitive SciencesRehabilitation3209 NeurosciencesJournal ArticleOpenAccess10.1177/15459683261445440