Biotin-kodecytes - novel function-spacer-lipid (FSL) modified cells capable of being recovered from the circulation after 3 days

Date
2010-06
Authors
Oliver, C
Blake, D
Ferguson, S
Bovin, N
Henry, S
Supervisor
Item type
Conference Contribution
Degree name
Journal Title
Journal ISSN
Volume Title
Publisher
John Wiley & Sons Ltd
Abstract

The ability to modify a population of blood cells with both an antigen of interest and an identification-recovery label, infuse them into the circulation of an animal, and then visualize or recover a sample of the infused cells some hours-days later for analysis, is now possible through the use of FSL (function-spacer-lipid) constructs. FSL constructs are analogous in structure to a flower and consist of three components; a functional head group (like the flower head), a pacer (like a stalk) and a diacylipid tail (the anchoring roots). All FSLs are biocompatible and allow users to introduce novel functional moieties to the membrane surface of living cells.

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Source
Federation of European Biochemical Societies(FEBS) Journal, Special Issue: Abstracts of the 35th FEBS Congress, Gothenburg, Sweden, vol.277(Suppl. 1), pp.50 - 51
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