Biotin-kodecytes - novel function-spacer-lipid (FSL) modified cells capable of being recovered from the circulation after 3 days

Oliver, C
Blake, D
Ferguson, S
Bovin, N
Henry, S
Item type
Conference Contribution
Degree name
Journal Title
Journal ISSN
Volume Title
John Wiley & Sons Ltd

The ability to modify a population of blood cells with both an antigen of interest and an identification-recovery label, infuse them into the circulation of an animal, and then visualize or recover a sample of the infused cells some hours-days later for analysis, is now possible through the use of FSL (function-spacer-lipid) constructs. FSL constructs are analogous in structure to a flower and consist of three components; a functional head group (like the flower head), a pacer (like a stalk) and a diacylipid tail (the anchoring roots). All FSLs are biocompatible and allow users to introduce novel functional moieties to the membrane surface of living cells.

Federation of European Biochemical Societies(FEBS) Journal, Special Issue: Abstracts of the 35th FEBS Congress, Gothenburg, Sweden, vol.277(Suppl. 1), pp.50 - 51
Rights statement
Copyright © 2010 John Wiley & Sons. All rights reserved. Authors retain the right to place his/her pre-publication version of the work on a personal website or institutional repository. This article may not exactly replicate the final version published in (please see citation) as it is not a copy of this record. An electronic version of this article can be found online at: (Please see Publisher’s Version)