Inkjet printing of Function-Spacer-Lipid (FSL) biomolecules

Date
2011-02-07
Authors
Barr, K
Diegel, O
Parker, S
Henry, SM
Supervisor
Item type
Conference Contribution
Degree name
Journal Title
Journal ISSN
Volume Title
Publisher
AUT University
Abstract

FSL constructs (KODE Biotech Limited) consist of 3 parts: a functional head group (F), a spacer (S) and a lipid tail (L). The lipid tail acts as an anchor to localise the functional head group to a lipophilic surface, e.g. a cell membrane. In addition to satisfying the requirement for biocompatibility, the ability of the FSL constructs to disperse easily in water allows solutions of the constructs to be substituted for the ink in inkjet printer cartridges. FSL constructs can then be printed onto solid surfaces using a standard desktop printer and are being used to develop prototype diagnostic assays (Bovin et al, 2011). The constructs can be printed as words or in desired patterns. FSL constructs comprising ABO blood group antigens or biotin as the functional head groups (F) have been printed onto silica, nitrocellulose and paper. The printed constructs have then been used to identify antibodies in different biological samples. The inkjet printing of FSL constructs provides the advantage that multiple antibodies can be identified and quantified in the same reaction well. The inkjet printing of FSL constructs is proving to be a fast, inexpensive and flexible method of producing diagnostic assays.

Description
Keywords
Bioprinting , 3D printing , tissue engineering , inkjet printing of biomaterials
Source
Proceedings of the 2011 New Zealand Rapid Product Development Conference, Auckland, New Zealand, pp.1-4
DOI
Rights statement
Copyright © 2010 Creative Industries Research Institute AUT. All Rights Reserved. Authors retain the right to place his/her publication version of the work on a personal website or institutional repository for non commercial purposes. The definitive version was published in (see Citation). The original publication is available at (see Publisher’s Version).