AUT LibraryAUT
View Item 
  •   Open Research
  • Faculties
  • Faculty of Health and Environmental Sciences
  • School of Interprofessional Health Studies
  • View Item
  •   Open Research
  • Faculties
  • Faculty of Health and Environmental Sciences
  • School of Interprofessional Health Studies
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Effect of Lactobacillus Rhamnosus Probiotic in Early Pregnancy on Plasma Conjugated Bile Acids in a Randomised Controlled Trial

Chen, Y; Lu, J; Wickens, K; Stanley, T; Maude, R; Stone, P; Barthow, C; Crane, J; Mitchell, EA; Merien, F; Murphy, R
Thumbnail
View/Open
Journal article (2.803Mb)
Permanent link
http://hdl.handle.net/10292/13974
Metadata
Show full metadata
Abstract
We have previously shown that probiotic supplementation with Lactobacillus rhamnosus HN001 (HN001) led to a reduced incidence of gestational diabetes mellitus (GDM). Here we investigate whether HN001 supplementation resulted in alterations in fasting lipids, insulin resistance, or bile acids (BAs) during pregnancy. Fasting plasma samples collected at 24-30 weeks' gestation, from 348 women randomised at 14-16 weeks' gestation to consume daily probiotic HN001 (n = 172) or a placebo (n = 176) were analysed for lipids, insulin, glucose and BAs. Women supplemented with HN001 had lower fasting glucose compared with placebo (p = 0.040), and lower GDM. Significant differences were found in fasting insulin, HOMA-IR, low density lipoprotein-cholesterol (LDL-c), high density lipoprotein (HDL)-c, triglycerides, total cholesterol, and BAs by GDM status. Lower fasting conjugated BAs were seen in women receiving HN001. A significant decrease of glycocholic acid (GCA) was found in older (age ≥ 35) women who received HN001 (p = 0.005), while GDM women showed significant reduced taurodeoxycholic acid (TDCA) (p = 0.018). Fasting conjugated BA was positively correlated with fasting glucose (r = 0.136, p = 0.020) and fasting insulin (r = 0.113, p = 0.036). Probiotic HN001 supplementation decreases conjugated BAs and might play a role in the improvement of glucose metabolism in women with pregnancy.
Keywords
LC-MS; Bile acids; Conjugated bile acids; Gestational diabetes; Insulin sensitivity; Probiotics; Randomised controlled trial
Date
2021
Source
Nutrients, 13(1), 209. doi:10.3390/nu13010209
Item Type
Journal Article
Publisher
MDPI AG
DOI
10.3390/nu13010209
Publisher's Version
https://www.mdpi.com/2072-6643/13/1/209
Rights Statement
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

Contact Us
  • Admin

Hosted by Tuwhera, an initiative of the Auckland University of Technology Library

 

 

Browse

Open ResearchTitlesAuthorsDateSchool of Interprofessional Health StudiesTitlesAuthorsDate

Alternative metrics

 

Statistics

For this itemFor all Open Research

Share

 
Follow @AUT_SC

Contact Us
  • Admin

Hosted by Tuwhera, an initiative of the Auckland University of Technology Library