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dc.contributor.authorDeshpande, Aen_NZ
dc.contributor.authorMiller-Petrie, MKen_NZ
dc.contributor.authorLindstedt, PAen_NZ
dc.contributor.authorBaumann, MMen_NZ
dc.contributor.authorJohnson, KBen_NZ
dc.contributor.authorBlacker, BFen_NZ
dc.contributor.authorAbbastabar, Hen_NZ
dc.contributor.authorAbd-Allah, Fen_NZ
dc.contributor.authorAbdelalim, Aen_NZ
dc.contributor.authorAbdollahpour, Ien_NZ
dc.contributor.authorAbegaz, KHen_NZ
dc.contributor.authorAbejie, ANen_NZ
dc.contributor.authorAbreu, LGen_NZ
dc.contributor.authorAbrigo, MRMen_NZ
dc.contributor.authorAbualhasan, Aen_NZ
dc.contributor.authorAccrombessi, MMKen_NZ
dc.contributor.authorAdamu, AAen_NZ
dc.contributor.authorAdebayo, OMen_NZ
dc.contributor.authorAdedeji, IAen_NZ
dc.contributor.authorAdedoyin, RAen_NZ
dc.contributor.authorAdekanmbi, Ven_NZ
dc.contributor.authorAdetokunboh, OOen_NZ
dc.contributor.authorAdhikari, TBen_NZ
dc.contributor.authorAfarideh, Men_NZ
dc.contributor.authorAgudelo-Botero, Men_NZ
dc.contributor.authorAhmadi, Men_NZ
dc.contributor.authorAhmadi, Ken_NZ
dc.contributor.authorAhmed, MBen_NZ
dc.contributor.authorAhmed, AEen_NZ
dc.contributor.authorAkalu, TYen_NZ
dc.contributor.authorAkanda, ASen_NZ
dc.contributor.authorAlahdab, Fen_NZ
dc.contributor.authorAl-Aly, Zen_NZ
dc.contributor.authorAlam, Sen_NZ
dc.contributor.authorAlam, Nen_NZ
dc.contributor.authorAlamene, GMen_NZ
dc.contributor.authorAlanzi, TMen_NZ
dc.contributor.authorAlbright, Jen_NZ
dc.contributor.authorAlbujeer, Aen_NZ
dc.contributor.authorAlcalde-Rabanal, JEen_NZ
dc.contributor.authorAlebel, Aen_NZ
dc.contributor.authorAlemu, ZAen_NZ
dc.contributor.authorAli, Men_NZ
dc.contributor.authorAlijanzadeh, Men_NZ
dc.contributor.authorAlipour, Ven_NZ
dc.contributor.authorAljunid, SMen_NZ
dc.contributor.authorAlmasi, Aen_NZ
dc.contributor.authorAlmasi-Hashiani, Aen_NZ
dc.contributor.authorAl-Mekhlafi, HMen_NZ
dc.contributor.authorAltirkawi, KAen_NZ
dc.contributor.authorAlvis-Guzman, Nen_NZ
dc.contributor.authorAlvis-Zakzuk, NJen_NZ
dc.contributor.authorAmini, Sen_NZ
dc.contributor.authorAmit, AMLen_NZ
dc.contributor.authorAmul, GGHen_NZ
dc.contributor.authorAndrei, CLen_NZ
dc.contributor.authorAnjomshoa, Men_NZ
dc.contributor.authorAnsariadi, Aen_NZ
dc.contributor.authorAntonio, CATen_NZ
dc.contributor.authorAntony, Ben_NZ
dc.contributor.authorAntriyandarti, Een_NZ
dc.contributor.authorArabloo, Jen_NZ
dc.contributor.authorAref, HMAen_NZ
dc.contributor.authorAremu, Oen_NZ
dc.contributor.authorArmoon, Ben_NZ
dc.contributor.authorArora, Aen_NZ
dc.contributor.authorAryal, KKen_NZ
dc.contributor.authorArzani, Aen_NZ
dc.contributor.authorAsadi-Aliabadi, Men_NZ
dc.contributor.authorAsmelash, Den_NZ
dc.contributor.authorAtalay, HTen_NZ
dc.contributor.authorAthari, SMen_NZ
dc.contributor.authorAthari, SSen_NZ
dc.contributor.authorAtre, SRen_NZ
dc.contributor.authorAusloos, Men_NZ
dc.contributor.authorAwasthi, Sen_NZ
dc.contributor.authorAwoke, Nen_NZ
dc.contributor.authorAyala Quintanilla, BPen_NZ
dc.contributor.authorAyano, Gen_NZ
dc.contributor.authorAyanore, MAen_NZ
dc.contributor.authorAynalem, YAen_NZ
dc.contributor.authorAzari, Sen_NZ
dc.contributor.authorAzman, ASen_NZ
dc.contributor.authorBabaee, Een_NZ
dc.contributor.authorBadawi, Aen_NZ
dc.contributor.authorBagherzadeh, Men_NZ
dc.contributor.authorBakkannavar, SMen_NZ
dc.contributor.authorBalakrishnan, Sen_NZ
dc.contributor.authorBanach, Men_NZ
dc.contributor.authorBanoub, JAMen_NZ
dc.contributor.authorBarac, Aen_NZ
dc.contributor.authorBarboza, MAen_NZ
dc.contributor.authorBärnighausen, TWen_NZ
dc.contributor.authorBasu, Sen_NZ
dc.contributor.authorBay, VDen_NZ
dc.contributor.authorBayati, Men_NZ
dc.contributor.authorBedi, Nen_NZ
dc.contributor.authorBeheshti, Men_NZ
dc.contributor.authorBehzadifar, Men_NZ
dc.contributor.authorBehzadifar, Men_NZ
dc.date.accessioned2020-09-07T01:04:58Z
dc.date.available2020-09-07T01:04:58Z
dc.date.copyright2020en_NZ
dc.identifier.citationLancet Global Health, 2020-09-01, Volume 8, Issue 9, Pages e1186-e1194.
dc.identifier.issn2214-109Xen_NZ
dc.identifier.issn2214-109Xen_NZ
dc.identifier.urihttp://hdl.handle.net/10292/13636
dc.description.abstractBackground: Lymphatic filariasis is a neglected tropical disease that can cause permanent disability through disruption of the lymphatic system. This disease is caused by parasitic filarial worms that are transmitted by mosquitos. Mass drug administration (MDA) of antihelmintics is recommended by WHO to eliminate lymphatic filariasis as a public health problem. This study aims to produce the first geospatial estimates of the global prevalence of lymphatic filariasis infection over time, to quantify progress towards elimination, and to identify geographical variation in distribution of infection. Methods: A global dataset of georeferenced surveyed locations was used to model annual 2000–18 lymphatic filariasis prevalence for 73 current or previously endemic countries. We applied Bayesian model-based geostatistics and time series methods to generate spatially continuous estimates of global all-age 2000–18 prevalence of lymphatic filariasis infection mapped at a resolution of 5 km2 and aggregated to estimate total number of individuals infected. Findings: We used 14 927 datapoints to fit the geospatial models. An estimated 199 million total individuals (95% uncertainty interval 174–234 million) worldwide were infected with lymphatic filariasis in 2000, with totals for WHO regions ranging from 3·1 million (1·6–5·7 million) in the region of the Americas to 107 million (91–134 million) in the South-East Asia region. By 2018, an estimated 51 million individuals (43–63 million) were infected. Broad declines in prevalence are observed globally, but focal areas in Africa and southeast Asia remain less likely to have attained infection prevalence thresholds proposed to achieve local elimination. Interpretation: Although the prevalence of lymphatic filariasis infection has declined since 2000, MDA is still necessary across large populations in Africa and Asia. Our mapped estimates can be used to identify areas where the probability of meeting infection thresholds is low, and when coupled with large uncertainty in the predictions, indicate additional data collection or intervention might be warranted before MDA programmes cease. Funding: Bill & Melinda Gates Foundation.en_NZ
dc.publisherElsevier
dc.relation.urihttps://www.clinicalkey.com.au/#!/content/playContent/1-s2.0-S2214109X20302862
dc.rights© 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY 4.0 license.
dc.titleThe Global Distribution of Lymphatic Filariasis, 2000–18: A Geospatial Analysisen_NZ
dc.typeJournal Article
dc.rights.accessrightsOpenAccessen_NZ
dc.identifier.doi10.1016/S2214-109X(20)30286-2en_NZ
aut.relation.endpagee1194
aut.relation.issue9en_NZ
aut.relation.startpagee1186
aut.relation.volume8en_NZ
pubs.elements-id391451
aut.relation.journalThe Lancet Global Healthen_NZ


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