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Structural Dependence of Sulfated Polysaccharide for Diabetes Management: Fucoidan From Undaria pinnatifida Inhibiting α-glucosidase More Strongly Than α-amylase and Amyloglucosidase

Koh, HSA; Lu, J; Zhou, W
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http://hdl.handle.net/10292/13554
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Abstract
Fucoidan refers to a group of sulfated polysaccharide that is commonly obtained from various species of brown seaweed. Fucoidan has gained increased popularity among researchers in the recent years due to its numerous biological activities, including its inhibitory effects against starch hydrolyzing enzymes such as α-amylase and α-glucosidase. This highlights the potential of fucoidan as an antidiabetic agent in the management and prevention of diabetes mellitus. In this study, the inhibitory effects of fucoidan isolated from the New Zealand Undaria pinnatifida seaweed species against three starch hydrolyzing enzymes-α-amylase, α-glucosidase, and amyloglucosidase-was investigated. It was demonstrated that while the fucoidan exhibited significant inhibitory effects against all the three starch hydrolases, it is an uncompetitive inhibitor of α-amylase and amyloglucosidase, and is a competitive inhibitor of α-glucosidase. Moreover, it exhibited significantly stronger inhibitory effects against α-glucosidase than α-amylase, thus having the desirable characteristics as an antidiabetic agent.
Keywords
Diabetes; Undaria pinnatifida; Amyloglucosidase; Fucoidan; α-amylase; α-glucosidase
Date
2020
Source
Frontiers in Pharmacology, 11, 831.
Item Type
Journal Article
Publisher
Frontiers Media
DOI
10.3389/fphar.2020.00831
Publisher's Version
https://www.frontiersin.org/articles/10.3389/fphar.2020.00831/full
Rights Statement
Copyright © 2020 Koh, Lu and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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