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dc.contributor.authorJowitt, Len_NZ
dc.contributor.editorGout, IGen_NZ
dc.date.accessioned2019-01-22T22:22:02Z
dc.date.available2019-01-22T22:22:02Z
dc.date.copyright2017-05-04en_NZ
dc.identifier.citationIntegrated Molecular Medicine, 4: DOI: 10.15761/IMM.1000286
dc.identifier.issn2056-6360en_NZ
dc.identifier.urihttp://hdl.handle.net/10292/12174
dc.description.abstractThe primary aim of the study was to determine differences in the hormonal status (TSH, T3, and T4) between healthy participants and participants with Hashimoto’s thyroiditis. The secondary aim of the study was to assess plasma selenium nutritional status and its relationships with the serum levels of thyroid hormones in both of the groups. This study is a pilot and a cross-sectional. Study participants were assigned into two groups, the control group with healthy participants (n=13) and a group of women with Hashimoto’s thyroiditis (n=8). Any change in the participants’ daily routine was not required. For the measurement of plasma selenium, thyroid stimulating hormone, tetra iodothyronine, and triiodothyronine, creatinine, and glomerular filtration rate, participants’ non-fasting blood samples were taken. Two women with subclinical hypothyroidism were excluded from the statistical data analyses. Women with Hashimoto’s thyroiditis were older, had higher tetra iodothyronine level, low triiodothyronine/tetra iodothyronine ratio, higher plasma selenium levels, and similar triiodothyronine plasma levels to women in the control group. Significant relationships between triiodothyronine and selenium,  triiodothyronine were identified in the group of women with Hashimoto’s thyroiditis. There was a moderate selenium deficiency in both of the groups that affected more women with hypothyroidism. Compromised peripheral deiodination in women with hypothyroidism required increased L-thyroxine dosing, which in turn increased the level of tetra iodothyronine, and decreased pituitary thyroid stimulating hormone, in order to achieve the desired level of the triiodothyronine. In order to increase plasma selenium level, recent research has suggested that selenium supplementation with selenomethionine or selenium selenite, might also slow down the process of thyroid destruction by thyroid autoantibodies in Hashimoto’s thyroiditis. In the past, the process of selenium supplementation had variable success rates. Therefore, further research is warranted.en_NZ
dc.languageEnglishen_NZ
dc.publisherOpen Access Text (OAT)en_NZ
dc.relation.urihttps://www.oatext.com/selenium-and-thyroid-health-in-nz-european-women.phpen_NZ
dc.rights© 2017 Jowitt L. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.subjectNew Zealanden_NZ
dc.subjectSeleniumen_NZ
dc.subjectHashimoto's autoimmune thyroiditisen_NZ
dc.subjectL-thyroxineen_NZ
dc.subjectSelenocysteineen_NZ
dc.titleSelenium and Thyroid Health in NZ European Womenen_NZ
dc.typeJournal Article
dc.rights.accessrightsOpenAccessen_NZ
dc.identifier.doi10.15761/IMM.1000286en_NZ
aut.relation.articlenumber6en_NZ
aut.relation.endpage5
aut.relation.issue3en_NZ
aut.relation.pages5
aut.relation.startpage1
aut.relation.volume4en_NZ
pubs.elements-id297464
aut.relation.journalIntegrative molecular medicineen_NZ


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