Browsing School of Interprofessional Health Studies by Author "McKeage, M"

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Identification of MRP2 As a Targetable Factor Limiting Oxaliplatin Accumulation and Response in Gastrointestinal Cancer

Myint, K; Biswas, R; Li, Y; Jong, N; Jamieson, S; Liu, J; Han, C; Squire, C; Merien, F; Lu, J; Nakanishi, T; Tamai, I; McKeage, M (Nature Publishing Group, 2019)

Oxaliplatin is important for the clinical treatment of colorectal cancer and other gastrointestinal malignancies, but tumour resistance is limiting. Several oxaliplatin transporters were previously identified but their ...
Transport-mediated Oxaliplatin Resistance Associated With Endogenous Overexpression of MRP2 in Caco-2 and PANC-1 Cells

Biswas, R; Bugde, P; He, J; Merien, F; Lu, J; Liu, DX; Myint, K; Liu, J; McKeage, M; Li, Y (MDPI AG, 2019)

Our recent publications showed that multidrug resistance protein 2 (MRP2, encoded by the ABCC2 gene) conferred oxaliplatin resistance in human liver cancer HepG2 cells. However, the contribution of MRP2 to oxaliplatin ...