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dc.contributor.authorStewart, Sen_NZ
dc.contributor.authorDalbeth, Nen_NZ
dc.contributor.authorVandal, AVen_NZ
dc.contributor.authorAllen, Ben_NZ
dc.contributor.authorMiranda, Ren_NZ
dc.contributor.authorRome, Ken_NZ
dc.date.accessioned2017-05-28T20:53:12Z
dc.date.available2017-05-28T20:53:12Z
dc.date.copyright2017-05-25en_NZ
dc.identifier.citationJournal of Foot and Ankle Research (2017) 10:22 DOI 10.1186/s13047-017-0203-8
dc.identifier.issn1757-1146en_NZ
dc.identifier.urihttp://hdl.handle.net/10292/10494
dc.description.abstractBackground: The first metatatarsophalangeal joint (1st MTP joint) is a common location for sonographic evidence of urate deposition in people with gout and asymptomatic hyperuricaemia. However, it is unclear whether these are related to clinically-assessed pain and function. This study aimed to determine the association between ultrasound features and clinical characteristics of the 1st MTP joint in people with gout, asymptomatic hyperuricaemia and age- and sex-matched normouricaemic individuals. Methods: Twenty-three people with gout, 29 with asymptomatic hyperuricaemia and 34 with normouricaemia participated in a cross-sectional study. No participant had clinical evidence of acute inflammatory arthritis at the time of assessment. Four sonographic features at the 1st MTP joint were analysed: double contour sign, tophus, bone erosion and synovitis. Clinical characteristics included in the analysis were 1st MTP joint pain, overall foot pain and disability, 1st MTP joint temperature, 1st MTP joint range of motion and gait velocity. Statistical analyses adjusted for the diagnostic group of the participant. Results: After accounting for the diagnostic group, double contour sign was associated with higher foot pain and disability scores (P < 0.001). Ultrasound tophus was associated with higher foot pain and disability scores (P < 0.001), increased temperature (P = 0.005), and reduced walking velocity (P = 0.001). No associations were observed between ultrasound synovitis or erosion and the clinical characteristics. Conclusions: Ultrasound features of urate crystal deposition, rather than soft tissue inflammation or bone erosion, are associated with clinical measures of foot-related functional impairment and disability even in the absence of clinical evidence of current acute inflammatory arthritis. This association persisted regardless of the diagnosis of the participant as having gout or asymptomatic hyperuricaemia.
dc.publisherBioMed Centralen_NZ
dc.relation.urihttps://jfootankleres.biomedcentral.com/articles/10.1186/s13047-017-0203-8
dc.rights© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.subjectGout; Foot; Hyperuricemia; Ultrasonography
dc.titleAre Ultrasound Features at the First Metatarsophalangeal Joint Associated With Clinically-assessed Pain and Function? A Study of People With Gout, Asymptomatic Hyperuricaemia and Normouricaemiaen_NZ
dc.typeJournal Article
dc.rights.accessrightsOpenAccessen_NZ
dc.identifier.doi10.1186/s13047-017-0203-8
pubs.elements-id280777
aut.relation.journalJournal of Foot and Ankle Researchen_NZ


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