NISAN - the National Institute for Stroke and Applied Neurosciences

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https://hdl.handle.net/10292/10244

Institute Director: Professor Valery Feigin

Deputy Director: Associate Professor Alice Theadom



The National Institute for Stroke and Applied Neurosciences (NISAN) conducts epidemiological studies and clinical trials to improve health and outcomes in people with major neurological disorders. Current research programmes focus on:
  • Stroke
  • Traumatic brain injury
  • Neuromuscular disorders
Research with this aim is unique in New Zealand and NISAN is a hub for information sharing and developing a cohesive network between existing research and clinical groups with interests in:
  • Neuroepidemiology
  • Public health
  • Neurorehabilitation
  • Neuropsychology
  • Biostatistics

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Browsing NISAN - the National Institute for Stroke and Applied Neurosciences by Subject "0605 Microbiology"

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    National Plans and Awareness Campaigns as Priorities for Achieving Global Brain Health
    (Elsevier BV, 2024) Winter, Sebastian F; Walsh, Donna; Catsman-Berrevoets, Coriene; Feigin, Valery; Destrebecq, Frédéric; Dickson, Suzanne L; Leonardi, Matilde; Hoemberg, Volker; Tassorelli, Cristina; Ferretti, Maria Teresa; Dé, Anna; Chadha, Antonella Santuccione; Lynch, Chris; Bakhtadze, Sophia; Saylor, Deanna; Hwang, Soonmyung; Rostasy, Kevin; Kluger, Benzi M; Wright, Claire; Zee, Phyllis C; Dodick, David W; Jaarsma, Joke; Owolabi, Mayowa O; Zaletel, Jelka; Albreht, Tit; Dhamija, Rajinder K; Helme, Anne; Laurson-Doube, Joanna; Amos, Action; Baingana, Florence K; Baker, Gus A; Sofia, Francesca; Galvin, Orla; Hawrot, Tadeusz
    Summary Neurological conditions are the leading cause of death and disability combined. This public health crisis has become a global priority with the introduction of WHO's Intersectoral Global Action Plan on Epilepsy and Other Neurological Disorders 2022–2031 (IGAP). 18 months after this plan was adopted, global neurology stakeholders, including representatives of the OneNeurology Partnership (a consortium uniting global neurology organisations), take stock and advocate for urgent acceleration of IGAP implementation. Drawing on lessons from relevant global health contexts, this Health Policy identifies two priority IGAP targets to expedite national delivery of the entire 10-year plan: namely, to update national policies and plans, and to create awareness campaigns and advocacy programmes for neurological conditions and brain health. To ensure rapid attainment of the identified priority targets, six strategic drivers are proposed: universal community awareness, integrated neurology approaches, intersectoral governance, regionally coordinated IGAP domestication, lived experience-informed policy making, and neurological mainstreaming (advocating to embed brain health into broader policy agendas). Contextualised with globally emerging IGAP-directed efforts and key considerations for intersectoral policy design, this novel framework provides actionable recommendations for policy makers and IGAP implementation partners. Timely, synergistic pursuit of the six drivers might aid WHO member states in cultivating public awareness and policy structures required for successful intersectoral roll-out of IGAP by 2031, paving the way towards brain health for all.
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    The Burden of Neurological Conditions in North Africa and the Middle East, 1990–2019: A Systematic Analysis of the Global Burden of Disease Study 2019
    (Elsevier, 2024) GBD 2019 North Africa and Middle East Neurology Collaborators; Feigin, VL
    Summary Background The burden of neurological conditions in north Africa and the Middle East is increasing. We aimed to assess the changes in the burden of neurological conditions in this super-region to aid with future decision making. Methods In this analysis of the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 data, we examined temporal trends of disability-adjusted life-years (DALYs; deaths and disabilities combined), deaths, incident cases, and prevalent cases of 14 major neurological conditions and eight subtypes in 21 countries in the north Africa and the Middle East super-region. Additionally, we assessed neurological DALYs due to 22 potentially modifiable risk factors, within four levels of classification, during the period 1990–2019. We used a Bayesian modelling estimation approach, and generated 95% uncertainty intervals (UIs) for final estimates on the basis of the 2·5th and 97·5th percentiles of 1000 draws from the posterior distribution. Findings In 2019, there were 441·1 thousand (95% UI 347·2–598·4) deaths and 17·6 million (12·5–24·7) neurological DALYs in north Africa and the Middle East. The leading causes of neurological DALYs were stroke, migraine, and Alzheimer's disease and other dementias (hereafter dementias). In north Africa and the Middle East in 2019, 85·8% (82·6–89·1) of stroke and 39·9% (26·4–54·7) of dementia age-standardised DALYs were attributable to modifiable risk factors. North Africa and the Middle East had the highest age-standardised DALY rates per 100 000 population due to dementia (387·0 [172·0–848·5]), Parkinson's disease (84·4 [74·7–103·2]), and migraine (601·4 [107·0–1371·8]) among the global super-regions. Between 1990 and 2019, there was a decrease in the age-standardised DALY rates related to meningitis (–75·8% [–81·1 to –69·5]), tetanus (–88·2% [–93·9 to –76·1]), stroke (–32·0% [–39·1 to –23·3]), intracerebral haemorrhage (–51·7% [–58·2 to –43·8]), idiopathic epilepsy (–26·2% [–43·6 to –1·1]), and subarachnoid haemorrhage (–62·8% [–71·6 to –41·0]), but for all other neurological conditions there was no change. During 1990–2019, the number of DALYs due to dementias, Parkinson's disease, multiple sclerosis, ischaemic stroke, and headache disorder (ie, migraine and tension-type headache) more than doubled in the super-region, and the burden of years lived with disability (YLDs), incidence, and prevalence of multiple sclerosis, motor neuron disease, Parkinson's disease, and ischaemic stroke increased both in age-standardised rate and count. During this period, the absolute burden of YLDs due to head and spinal injuries almost doubled. Interpretation The increasing burden of neurological conditions in north Africa and the Middle East accompanies the increasing ageing population. Stroke and dementia are the primary causes of neurological disability and death, primarily attributable to common modifiable risk factors. Synergistic, systematic, lifetime, and multi-sectoral interventions aimed at preventing or mitigating the burden are needed.
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