Repeatability Characteristics of Insulin Response Patterns and Measures of Insulin Resistance

Simple item page
aut.relation.issue1en_NZ
aut.relation.journalJournal of Insulin Resistanceen_NZ
aut.relation.volume4en_NZ
aut.researcherDrabsch, Julie
dc.contributor.authorCrofts, CAPen_NZ
dc.contributor.authorWheldon, MCen_NZ
dc.contributor.authorZinn, Cen_NZ
dc.contributor.authorMerien, Fen_NZ
dc.contributor.authorSchofield, Gen_NZ
dc.date.accessioned2019-08-01T01:18:59Z
dc.date.available2019-08-01T01:18:59Z
dc.date.copyright2019en_NZ
dc.date.issued2019en_NZ
dc.description.abstractBackground: Hyperinsulinaemia is emerging as an independent risk factor for metabolic disease, but diagnostic measures are limited. It is plausible that insulin resistance measures, such as homeostatic model assessment (HOMA) type 2 variants, may model hyperinsulinaemia, but repeatability data are limited. Kraft and Hayashi insulin response patterns may not only add value in diagnosing hyperinsulinaemia, but also lack suitable repeatability data. Aim: The aim of this study was to investigate the repeatability of insulin response patterns, and fasting and dynamic measures of insulin resistance, and to determine whether these latter measures can predict the insulin response pattern. Setting: This study was conducted at Auckland University of Technology Millennium Institute’s sports performance laboratories. Methods: Oral glucose (100 g) tolerance tests were conducted weekly on eight people. Six people completed four tests, while two completed at least two tests. Each test assessed insulin resistance and response patterns. Insulin resistance measures included fasting tests (HOMA2, McAuley Index) and a dynamic test (oral glucose insulin sensitivity [OGIS]). The insulin response patterns were assessed with both Kraft and Hayashi methodologies. Repeatability characteristics of ordinal variables were assessed by Bland and Altman methods, while Fleiss’ κ was applied to categorical variables. Results: Fasting measures of insulin resistance recorded poor repeatability (HOMA2) or poor sensitivity (McAuley Index) compared to the dynamic measure (OGIS). Kraft insulin response patterns were more repeatable compared to Hayashi patterns, based on a combination of Fleiss’ κ (0.290 vs. 0.186,) p-value (0.15 vs. 0.798) and 95% confidence intervals. Conclusions: Both hyperinsulinaemia and insulin resistance should be dynamically assessed with a multi-sampled oral glucose tolerance test. Further investigations are required to confirm a preferred methodology.
dc.identifier.citationJournal of Insulin Resistance, 4(1), 9 pages. doi:https://doi.org/10.4102/jir.v4i1.44
dc.identifier.doi10.4102/jir.v4i1.44en_NZ
dc.identifier.issn2412-2785en_NZ
dc.identifier.issn2519-7533en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/12709
dc.languageenen_NZ
dc.publisherAOSISen_NZ
dc.relation.urihttps://insulinresistance.org/index.php/jir/article/view/44
dc.rightsAll articles published in this journal are licensed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license, unless otherwise stated. Website design & content: ©2019 AOSIS (Pty) Ltd. All rights reserved. No unauthorised duplication allowed.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectInsulin resistance; Hyperinsulinaemia; Kraft Patterns; Hayashi Patterns; HOMA; OGIS; McAuley Index; Insulin response pattern
dc.titleRepeatability Characteristics of Insulin Response Patterns and Measures of Insulin Resistanceen_NZ
dc.typeJournal Article
pubs.elements-id358541
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Interprofessional Health
pubs.organisational-data/AUT/Health & Environmental Science/Sports & Recreation
pubs.organisational-data/AUT/Health & Environmental Science/SPRINZ
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HI Interprofessional 2018 PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HS Sports & Recreation 2018 PBRF
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Crofts_2019_Repeatability.pdf
Size:
803.02 KB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
AUT Grant of Licence for Tuwhera Aug 2018.pdf
Size:
276.29 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
School of Interprofessional Health Studies