Role of Dietary Antioxidants in Diabetes: An Overview

Simple item page
aut.relation.articlenumber100666
aut.relation.endpage100666
aut.relation.journalFood Chemistry Advances
aut.relation.startpage100666
aut.relation.volume4
dc.contributor.authorShafras, M
dc.contributor.authorSabaragamuwa, R
dc.contributor.authorSuwair, M
dc.date.accessioned2024-03-24T23:43:19Z
dc.date.available2024-03-24T23:43:19Z
dc.date.issued2024-06-01
dc.description.abstractDiabetes mellitus (DM) is a devastating medical condition which has become one of the top ten causes of most deaths, with a 70 % increase since 2000. DM is characterised by elevated plasma glucose levels. The excess glucose levels have been found to have a causal link with the development of reactive oxygen species leading to oxidative stress. Failure of the body's intracellular antioxidant system to compensate for increased oxidative stress results in the activation of stress-sensitive intracellular signalling pathways and ultimately cellular damage, which leads to the pathogenesis of DM. It is evident that naturally occurring dietary antioxidants such as vitamins E, A, and C, plant polyphenols, carotenoids, flavonoids, glutathione, alpha-lipoic acid, and polyamines all provide significant protection against diabetes. According to research, antioxidant therapy protects the beta-cell against oxidative stress-induced apoptosis, preserves beta-cell function, and reduces diabetic-related complications. As a result, the use of naturally occurring antioxidants has increased dramatically, not only because of their natural therapeutic effects, but also because of the safety concerns associated with synthetic antioxidants, as well as their affordability and availability. This paper compiled the current research on the role of oxidative stress in diabetes and the significance of natural dietary antioxidants in mitigating that effect.
dc.identifier.citationFood Chemistry Advances, ISSN: 2772-753X (Print); 2772-753X (Online), Elsevier BV, 4, 100666-100666. doi: 10.1016/j.focha.2024.100666
dc.identifier.doi10.1016/j.focha.2024.100666
dc.identifier.issn2772-753X
dc.identifier.issn2772-753X
dc.identifier.urihttp://hdl.handle.net/10292/17370
dc.languageen
dc.publisherElsevier BV
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S2772753X24000625
dc.rights© 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.accessrightsOpenAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject3101 Biochemistry and Cell Biology
dc.subject32 Biomedical and Clinical Sciences
dc.subject31 Biological Sciences
dc.subjectDiabetes
dc.subjectComplementary and Integrative Health
dc.subjectNutrition
dc.subject5 Development of treatments and therapeutic interventions
dc.subject5.1 Pharmaceuticals
dc.subjectMetabolic and endocrine
dc.titleRole of Dietary Antioxidants in Diabetes: An Overview
dc.typeJournal Article
pubs.elements-id542745
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Role of dietary antioxidants in diabetes.pdf
Size:
721.04 KB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
Collections
School of Science