The Effects of Synthetically Modified Natural Compounds on ABC Transporters

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aut.relation.issue3en_NZ
aut.relation.journalPharmaceuticsen_NZ
aut.relation.volume10en_NZ
dark.contributor.authorDantzic, Den_NZ
dark.contributor.authorNoel, Pen_NZ
dark.contributor.authorMerien, Fen_NZ
dark.contributor.authorLiu, DXen_NZ
dark.contributor.authorLu, Jen_NZ
dark.contributor.authorHan, Hen_NZ
dark.contributor.authorMcKeage, MJen_NZ
dark.contributor.authorLi, Yen_NZ
dc.date.accessioned2018-11-18T22:05:06Z
dc.date.available2018-11-18T22:05:06Z
dc.date.copyright2018-09-01en_NZ
dc.date.issued2018-09-01en_NZ
dc.description.abstractMultidrug resistance (MDR) is a major hurdle which must be overcome to effectively treat cancer. ATP-binding cassette transporters (ABC transporters) play pivotal roles in drug absorption and disposition, and overexpression of ABC transporters has been shown to attenuate cellular/tissue drug accumulation and thus increase MDR across a variety of cancers. Overcoming MDR is one desired approach to improving the survival rate of patients. To date, a number of modulators have been identified which block the function and/or decrease the expression of ABC transporters, thereby restoring the efficacy of a range of anticancer drugs. However, clinical MDR reversal agents have thus far proven ineffective and/or toxic. The need for new, effective, well-tolerated and nontoxic compounds has led to the development of natural compounds and their derivatives to ameliorate MDR. This review evaluates whether synthetically modifying natural compounds is a viable strategy to generate potent, nontoxic, ABC transporter inhibitors which may potentially reverse MDR.en_NZ
dc.identifier.citationPharmaceutics, 10(3), 127. doi:10.3390/pharmaceutics10030127
dc.identifier.doi10.3390/pharmaceutics10030127en_NZ
dc.identifier.issn1999-4923en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/12034
dc.publisherMDPI
dc.relation.urihttps://www.mdpi.com/1999-4923/10/3/127
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectABC transporter; Drug disposition; Multidrug resistance; P-glycoprotein (P-gp); Breast cancer resistant protein (BCRP); Multidrug resistance-associated proteins (MRPs)
dc.titleThe Effects of Synthetically Modified Natural Compounds on ABC Transportersen_NZ
dc.typeJournal Article
pubs.elements-id343246
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Applied Science
pubs.organisational-data/AUT/Health & Environmental Science/Interprofessional Health
pubs.organisational-data/AUT/Health & Environmental Science/School of Science
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HA Science 2018 PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HI Interprofessional 2018 PBRF
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