Browsing Open Theses & Dissertations by Thesis Supervisor "Lu, Jun"
Now showing items 1-20 of 21
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Anti-proliferative Effect of Fucoxanthin on Human Pancreatic Cancer Cells
(Auckland University of Technology, 2015)Cancer is one of the major public health problems in the world. Pancreatic cancer is the 8th most common cause of cancer death worldwide because of its poor prognosis. New Zealand is the fourth highest cancer incidence ... -
Anti-proliferative potential of fucoidan on human prostate cancer cells
(Auckland University of Technology, 2016)Fucoidan is a sulphated polysaccharides from seaweed. In the present study, commercial crude and pure fucoidan from F. vesiculosus (CCF, CPF; purchased from sigma), crude fucoidan from New Zealand U. pinnatifida extracted ... -
Anticancer Potential of New Zealand Surf Clam Extracts
(Auckland University of Technology, 2019)The field of nutraceuticals, functional foods, and chemo-preventive compounds in the treatment/control of cancer is experiencing an increased awareness in both scientific and public domains. This study stems from my earlier ... -
The Antioxidant and Anticancer Potentials of New Zealand Manuka Honey and Thyme Honey
(Auckland University of Technology, 2016)This study was conducted to test the antioxidant and anticancer activities of New Zealand Manuka honey and Thyme honey. The antioxidant activity of these two types of honey were tested by using two antioxidant assays, 2, ... -
The Antioxidant Potentials of the New Zealand Surf Clams
(Auckland University of Technology, 2015)The antioxidant activities of the aqueous and ethanolic extracts of three New Zealand surf clam species (Tua Tua (Paphies donacina), Diamond Shell (Spisula aequilatera) and Storm shell (Mactra murchisoni)) were evaluated ... -
Bile Acids and FGF19 in the Remission of Type 2 Diabetes After Sleeve Gastrectomy and Gastric Bypass
(Auckland University of Technology, 2017)Prevalence of type 2 diabetes (T2DM) is increasing sharply. There is a direct relationship between obesity and T2DM. Currently, T2DM has no effective cure. However, there are several diabetes management such as pharmacotherapy, ... -
Determination of Human Plasma Bile Acid Metabolic Profiles by Liquid Chromatography-tandem Mass Spectrometry
(Auckland University of Technology, 2018)Metabolic diseases, particularly type 2 diabetes mellitus (T2DM), are becoming serious health issues globally. Metabolic diseases are associated with changes in a number of biomarkers, such as glucose, insulin, and ... -
Effect of Green Tea Extract in Reducing the Formation of Acrylamide From Bread Baking Process
(Auckland University of Technology, 2016)Bread is one of the most famous foods worldwide. It is consumed as a staple food for many Western countries and contains high content of carbohydrates. Nowadays, an increasing number of people prefer healthy foods. Tea ... -
Effect of Vibration Imposition on Aortic Muscle Tissue : An Explorative Study
(Auckland University of Technology, 2017)Aorta, the main artery of the human body has a pipe like structure and is tasked with carrying and distributing the oxygenated blood to the various parts of the human body. Development of small kink or obstruction, clinically ... -
The estimation of the digestibility of fucoidan extracted from New Zealand Undaria pinnatifida
(Auckland University of Technology, 2018)Undaria pinnatifida is an unwanted seaweed species in New Zealand that heavily infests local mussel farms. Fucoidan, a sulfated polysaccharide extracted from U. pinnatifida, is known to have greater number of bioactivities. ... -
The Fucoxanthin content and antioxidant properties of Undaria Pinnatifida from Marlborough Sound, New Zealand
(Auckland University of Technology, 2012)Undaria pinnatifida (U.pinnatifida) is a type of brown seaweed native to the temperate shores of Japan, Korea and China. It was introduced to New Zealand accidently through ships travelling from Asia in 1987. Since then, ... -
Identification of novel compounds in Undaria pinnatifida with anti-cancer potential
(Auckland University of Technology, 2012)In New Zealand, the rate of registered cancer cases increased significantly in recent years especially for breast, melanoma, colorectal cancer and lung cancer (Ministry of Health, 2008b). The success rate of cancer ... -
In Vitro SSAT Enzyme Activity Study Using Rat and Mouse Liver Tissue Preparations
(Auckland University of Technology, 2019)Spermidine/spermine N1-acetyltransferase (SSAT) is the enzyme which acetylates spermidine (Spd) to acetylspermidine (AcSpd). SSAT is also capable of acetylating polyamine analogues such as triethylenetetramine (TETA) to ... -
In Vitro Study of the Cytotoxic Effects of Low- and High-molecular-weight Fucoidan Extracted from New Zealand Seaweed Undaria Pinnatifida in MCF-7 and MDA-MB-231 Breast Cancer Cell Lines
(Auckland University of Technology, 2018)Breast cancer is known as the top cancer for women worldwide. It is estimated that every year over one million new cases of breast cancer are diagnosed and contribute largely to cancer related deaths. Chemotherapy, including ... -
An Investigation Into the Effects of Pressure Oscillations on Airway Smooth Muscle in Chronic Asthma
(Auckland University of Technology, 2018)The hyperconstriction of airway smooth muscle (ASM) is the main driving mechanism during an asthmatic attack. The airway lumen is reduced, resistance to airflow increases, and normal breathing becomes more difficult. The ... -
An Investigation of the Dynamic Response of Airway Smooth Muscle in Sensitized Animal Models
(Auckland University of Technology, 2014)Asthma is a chronic respiratory disease, characterized by inflammation, airway hyperresponsiveness (AHR) and obstruction of the airways. During an asthma attack, the contraction of airway smooth muscle (ASM) in combination ... -
MRP2 as a Targetable Oxaliplatin Resistance Factor in Gastrointestinal Cancer
(Auckland University of Technology, 2018)Despite the severe adverse effects, toxicity and limited efficacy due to the development of multidrug resistance (MDR), chemotherapy is still the treatment of choice for most of the cancer patients. One of the formidable ... -
Role of ABCC5 in Gemcitabine Resistance in Pancreatic Cancer
(Auckland University of Technology, 2019)Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive solid tumours. gemcitabine-based regimens have been used as front-line treatments for patients with advanced pancreatic cancer. gemcitabine may initially ... -
Study of Fucoidan Digestibility via an in Vitro Digestion System
(Auckland University of Technology, 2015)Fucoidan is a known health product mainly consumed orally. It is important to investigate the digestibility of fucoidan in order to understand how fucoidan exerts its health benefits. Our objective for this project is ... -
Treatment of Prostate Cancer With Fucoidan of Low Molecular Weights in Combination With Guanine-rich Oligonucleotide Therapy
(Auckland University of Technology, 2017)Three oncogenes, ErbB receptors, Ras proteins and nucleolin, may contribute to malignant transformation of healthy cells. Previously, mutant Ras was shown to be capable of activating ErbB receptors in a ligand-independent ...