Update: Rationale and design of the Sodium Lowering In Dialysate (SoLID) trial: A randomised controlled trial of low versus standard dialysate sodium concentration during hemodialysis for regression of left ventricular mass

Date
2015
Authors
Dunlop, JL
Vandal, AC
de Zoysa, JR
Gabriel, RS
Haloob, IA
Hood, CJ
Matheson, PJ
McGregor, DO
Rabindranath, KS
Semple, DJ
Supervisor
Item type
Journal Article
Degree name
Journal Title
Journal ISSN
Volume Title
Publisher
BioMed Central Ltd
Abstract

After the publication of our paper Dunlop et al. "Rationale and design of the Sodium Lowering In Dialysate (SoLID) trial: a randomised controlled trial of low versus standard dialysate sodium concentration during hemodialysis for regression of left ventricular mass", we became aware of further data correlating left ventricular (LV) mass index at baseline and their correpsonding mass at 12 months, using cardiac margnetic resonanace imaging (MRI) in patients on hemodialysis. The original published sample size for the SoLID trial of 118 was a conservative estimate, calculated using analysis of covariance and a within person Pearson's correlation for LV mass index of 0.75. New data communicated to the SoLID trial group has resulted in re-calcuation of the sample size, based upon a within person Pearson's correlation of 0.8 but otherwise unchanged assumptions. As a result, the SoLID trial will now recruit 96 participants.

Description
Keywords
Public Health; Internal Medicine; Repeated Measure; Research Council; Randomise Control Trial
Source
BMC Nephrology, 16(1), 120.
Rights statement
© Dunlop et al. 2015 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.