An organization's success in e-business is significantly affected by the quality of its website. However, many websites are unable to retain the attention of their customers, arguably because they only cater to some of the needs of their customers. This study adopts a design science approach to develop a new methodology for designing websites that addresses the psychological, sociological, and cognitive needs of individual users. The methodology is based on multidisciplinary principles drawn from the field of design, as they provide a framework for structuring the various concerns of users. This study contributes by developing a website design methodology anchored in users’ needs, so that the websites it produces are successful in achieving their goals.